Signal Transduction Antibodies 1
Anti-GABRA3 Antibody (CAB11636)
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- SKU:
- CAB11636
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-GABRA3 Antibody |
| Antibody SKU: | CAB11636 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-276 of human GABRA3 (NP_000799.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-276 of human GABRA3 (NP_000799.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QGES RRQE PGDF VKQD IGGL SPKH APDI PDDS TDNI TIFT RILD RLLD GYDN RLRP GLGD AVTE VKTD IYVT SFGP VSDT DMEY TIDV FFRQ TWHD ERLK FDGP MKIL PLNN LLAS KIWT PDTF FHNG KKSV AHNM TTPN KLLR LVDN GTLL YTMR LTIH AECP MHLE DFPM DVHA CPLK FGSY AYTT AEVV YSWT LGKN KSVE VAQD GSRL NQYD LLGH VVGT EIIR SSTG EYVV MTTH FHLK RKIG |
| Gene ID: | 2556 |
| Uniprot: | P34903 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 55kDa |
| Observed MW: | 55kDa |
| Synonyms: | GABRA3 |
| Background: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. |
| UniProt Protein Function: | GABRA3: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel Chromosomal Location of Human Ortholog: Xq28 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:benzodiazepine receptor activity; GABA-A receptor activity; protein binding Biological Process: transport |
| NCBI Summary: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P34903 |
| NCBI GenInfo Identifier: | 462149 |
| NCBI Gene ID: | 2556 |
| NCBI Accession: | P34903.1 |
| UniProt Secondary Accession: | P34903,Q8TAF9, |
| UniProt Related Accession: | P34903 |
| Molecular Weight: | 55,165 Da |
| NCBI Full Name: | Gamma-aminobutyric acid receptor subunit alpha-3 |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor alpha3 subunit |
| NCBI Official Symbol: | GABRA3 |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit alpha-3 |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit alpha-3 |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit alpha-3 |
| Protein Family: | Gamma-aminobutyric acid receptor |
| UniProt Gene Name: | GABRA3 |
| UniProt Entry Name: | GBRA3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GABRA3 antibody (CAB11636) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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