Epigenetics & Nuclear Signaling Antibodies 1
Anti-GABPA Antibody (CAB12047)
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- SKU:
- CAB12047
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-GABPA Antibody |
| Antibody SKU: | CAB12047 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GABPA (NP_002031.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Raji, HepG2, SKOV3, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GABPA (NP_002031.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTKR EAEE LIEI EIDG TEKA ECTE ESIV EQTY APAE CVSQ AIDI NEPI GNLK KLLE PRLQ CSLD AHEI CLQD IQLD PERS LFDQ GVKT DGTV QLSV QVIS |
| Gene ID: | 2551 |
| Uniprot: | Q06546 |
| Cellular Location: | Nucleus |
| Calculated MW: | 51kDa |
| Observed MW: | 60kDa |
| Synonyms: | GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 |
| Background: | This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | GABPA: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. Belongs to the ETS family. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 21q21.3 Cellular Component: nuclear chromatin; nucleoplasm; nucleus Molecular Function:DNA binding; protein binding; protein heterodimerization activity; transcription coactivator activity; transcription factor activity Biological Process: cell differentiation; mitochondrion organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q06546 |
| NCBI GenInfo Identifier: | 729553 |
| NCBI Gene ID: | 2551 |
| NCBI Accession: | Q06546.1 |
| UniProt Secondary Accession: | Q06546,Q12939, |
| UniProt Related Accession: | Q06546 |
| Molecular Weight: | 51,295 Da |
| NCBI Full Name: | GA-binding protein alpha chain |
| NCBI Synonym Full Names: | GA binding protein transcription factor alpha subunit |
| NCBI Official Symbol: | GABPA |
| NCBI Official Synonym Symbols: | NFT2; NRF2; NRF2A; E4TF1A; E4TF1-60; RCH04A07 |
| NCBI Protein Information: | GA-binding protein alpha chain |
| UniProt Protein Name: | GA-binding protein alpha chain |
| UniProt Synonym Protein Names: | Nuclear respiratory factor 2 subunit alpha; Transcription factor E4TF1-60 |
| Protein Family: | GA-binding protein |
| UniProt Gene Name: | GABPA |
| UniProt Entry Name: | GABPA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GABPA antibody (CAB12047) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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