Cell Biology Antibodies 2
Anti-FUCA2 Antibody (CAB12211)
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- SKU:
- CAB12211
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FUCA2 Antibody |
| Antibody SKU: | CAB12211 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 118-467 of human FUCA2 (NP_114409.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, Mouse kidney, Mouse heart, Mouse stomach, Rat kidney, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 118-467 of human FUCA2 (NP_114409.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ADIF QASG AKYI VLTS KHHE GFTL WGSE YSWN WNAI DEGP KRDI VKEL EVAI RNRT DLRF GLYY SLFE WFHP LFLE DESS SFHK RQFP VSKT LPEL YELV NNYQ PEVL WSDG DGGA PDQY WNST GFLA WLYN ESPV RGTV VTND RWGA GSIC KHGG FYTC SDRY NPGH LLPH KWEN CMTI DKLS WGYR REAG ISDY LTIE ELVK QLVE TVSC GGNL LMNI GPTL DGTI SVVF EERL RQMG SWLK VNGE AIYE THTW RSQN DTVT PDVW YTSK PKEK LVYA IFLK WPTS GQLF LGHP KAIL GATE VKLL GHGQ PLNW ISLE QNGI MVEL PQLT IHQM PCKW GWAL ALTN VI |
| Gene ID: | 2519 |
| Uniprot: | Q9BTY2 |
| Cellular Location: | Secreted |
| Calculated MW: | 19kDa/54kDa |
| Observed MW: | 45kDa |
| Synonyms: | FUCA2, dJ20N2.5 |
| Background: | This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1, 6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. |
| UniProt Protein Function: | FUCA2: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins. Belongs to the glycosyl hydrolase 29 family. |
| UniProt Protein Details: | Protein type:Secreted; EC 3.2.1.51; Glycan Metabolism - other glycan degradation; Hydrolase; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6q24 Cellular Component: extracellular space; lysosome Molecular Function:alpha-L-fucosidase activity; fucose binding Biological Process: fucose metabolic process; glycoside catabolic process; response to bacterium |
| NCBI Summary: | This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010] |
| UniProt Code: | Q9BTY2 |
| NCBI GenInfo Identifier: | 254763296 |
| NCBI Gene ID: | 2519 |
| NCBI Accession: | Q9BTY2.2 |
| UniProt Related Accession: | Q9BTY2 |
| Molecular Weight: | 77.7 kDa |
| NCBI Full Name: | Plasma alpha-L-fucosidase |
| NCBI Synonym Full Names: | alpha-L-fucosidase 2 |
| NCBI Official Symbol: | FUCA2 |
| NCBI Official Synonym Symbols: | dJ20N2.5 |
| NCBI Protein Information: | plasma alpha-L-fucosidase |
| UniProt Protein Name: | Plasma alpha-L-fucosidase |
| UniProt Synonym Protein Names: | Alpha-L-fucoside fucohydrolase 2; Alpha-L-fucosidase 2 |
| Protein Family: | Plasma alpha-L-fucosidase |
| UniProt Gene Name: | FUCA2 |
| UniProt Entry Name: | FUCO2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FUCA2 antibody (CAB12211) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using FUCA2 Rabbit pAb (CAB12211) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using FUCA2 Rabbit pAb (CAB12211) at dilution of 1:200 (40x lens). |
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