Anti-FUBP1 Antibody (CAB9077)

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SKU:
CAB9077
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
FBP
Synonyms:
FUBP
Synonyms:
hDH V
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:FUBP1 Rabbit mAb
Product Code:CAB9077
Size:20uL, 50uL, 100uL
Synonyms:FBP, FUBP, hDH V
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human FUBP1
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human FUBP1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8880
Uniprot:Q96AE4
Calculated MW:74kDa
Observed MW:75KDa
UniProt Protein Function:FBP1: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor; RNA-binding; Motility/polarity/chemotaxis; RNA splicing

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding; transcription factor activity; single-stranded DNA binding

Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Code:Q96AE4
NCBI GenInfo Identifier:116241370
NCBI Gene ID:8880
NCBI Accession:Q96AE4.3
UniProt Secondary Accession:Q96AE4,Q12828,
UniProt Related Accession:Q96AE4
Molecular Weight:653
NCBI Full Name:Far upstream element-binding protein 1
NCBI Synonym Full Names:far upstream element (FUSE) binding protein 1
NCBI Official Symbol:FUBP1  
NCBI Official Synonym Symbols:FBP; FUBP; hDH V  
NCBI Protein Information:far upstream element-binding protein 1; DNA helicase V
UniProt Protein Name:Far upstream element-binding protein 1
UniProt Synonym Protein Names:DNA helicase V; hDH V
Protein Family:Far upstream element-binding protein
UniProt Gene Name:FUBP1  
UniProt Entry Name:FUBP1_HUMAN
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