Metabolism Antibodies 3
Anti-FRAT1 Antibody (CAB16093)
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- SKU:
- CAB16093
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-FRAT1 Antibody |
| Antibody SKU: | CAB16093 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human FRAT1 (NP_005470.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse thymus, Mouse spleen, Rat testis, Rat spleen |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human FRAT1 (NP_005470.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HRLL QQLV LSGN LIKE AVRR LHSR RLQL RAKL PQRP LLGP LSAP VHEP PSPR SPRA ACSD PGAS GRAQ LRTG DGVL VPGS |
| Gene ID: | 10023 |
| Uniprot: | Q92837 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 29kDa |
| Observed MW: | 31kDa |
| Synonyms: | FRAT1 |
| Background: | The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. |
| UniProt Protein Function: | FRAT1: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. Belongs to the GSK-3-binding protein family. |
| UniProt Protein Details: | Protein type:Oncoprotein; Transcription regulation Chromosomal Location of Human Ortholog: 10q24.1 Cellular Component: cytosol |
| NCBI Summary: | The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q92837 |
| NCBI GenInfo Identifier: | 51338813 |
| NCBI Gene ID: | 10023 |
| NCBI Accession: | Q92837.3 |
| UniProt Secondary Accession: | Q92837,Q5JTI1, Q8NE74, Q8TDW9, |
| UniProt Related Accession: | Q92837 |
| Molecular Weight: | 29,093 Da |
| NCBI Full Name: | Proto-oncogene FRAT1 |
| NCBI Synonym Full Names: | frequently rearranged in advanced T-cell lymphomas 1 |
| NCBI Official Symbol: | FRAT1 |
| NCBI Protein Information: | proto-oncogene FRAT1 |
| UniProt Protein Name: | Proto-oncogene FRAT1 |
| UniProt Synonym Protein Names: | Frequently rearranged in advanced T-cell lymphomas 1; FRAT-1 |
| Protein Family: | F1 capsule antigen |
| UniProt Gene Name: | FRAT1 |
| UniProt Entry Name: | FRAT1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FRAT1 antibody (CAB16093) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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