Developmental Biology
Anti-FOXA3 Antibody (CAB16382)
- SKU:
- CAB16382
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-FOXA3 Antibody |
| Antibody SKU: | CAB16382 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOXA3 (NP_004488.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOXA3 (NP_004488.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLGS VKME AHDL AEWS YYPE AGEV YSPV TPVP TMAP LNSY MTLN PLSS PYPP GGLP ASPL PSGP LAPP APAA PLGP TFPG LGVS GGSS SSGY GAPG PGLV |
| Gene ID: | 3171 |
| Uniprot: | P55318 |
| Cellular Location: | Nucleus |
| Calculated MW: | 37kDa |
| Observed MW: | Refer to figures |
| Synonyms: | FOXA3, FKHH3, HNF3G, TCF3G |
| Background: | This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. |
| UniProt Protein Function: | FOXA3: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 19q13.32 Molecular Function:transcription factor activity Biological Process: cell glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55318 |
| NCBI GenInfo Identifier: | 16359111 |
| NCBI Gene ID: | 3171 |
| NCBI Accession: | BC016024 |
| UniProt Secondary Accession: | P55318,Q53F16, Q9UMW9, A9LYI5, |
| UniProt Related Accession: | P55318 |
| Molecular Weight: | 37,140 Da |
| NCBI Full Name: | Homo sapiens forkhead box A3, mRNA |
| NCBI Synonym Full Names: | forkhead box A3 |
| NCBI Official Symbol: | FOXA3 |
| NCBI Official Synonym Symbols: | FKHH3; HNF3G; TCF3G |
| NCBI Protein Information: | hepatocyte nuclear factor 3-gamma |
| UniProt Protein Name: | Hepatocyte nuclear factor 3-gamma |
| UniProt Synonym Protein Names: | Fork head-related protein FKH H3; Forkhead box protein A3; Transcription factor 3G; TCF-3G |
| Protein Family: | Hepatocyte nuclear factor |
| UniProt Gene Name: | FOXA3 |
| UniProt Entry Name: | FOXA3_HUMAN |
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