Developmental Biology

Anti-FOXA3 Antibody (CAB16382)

(No reviews yet) Write a Review
SKU:
CAB16382
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-FOXA3 Antibody
Antibody SKU:CAB16382
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOXA3 (NP_004488.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOXA3 (NP_004488.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLGS VKME AHDL AEWS YYPE AGEV YSPV TPVP TMAP LNSY MTLN PLSS PYPP GGLP ASPL PSGP LAPP APAA PLGP TFPG LGVS GGSS SSGY GAPG PGLV
Gene ID:3171
Uniprot:P55318
Cellular Location:Nucleus
Calculated MW:37kDa
Observed MW:Refer to figures
Synonyms:FOXA3, FKHH3, HNF3G, TCF3G
Background:This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved.
UniProt Protein Function:FOXA3: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 19q13.32

Molecular Function:transcription factor activity

Biological Process: cell glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]
UniProt Code:P55318
NCBI GenInfo Identifier:16359111
NCBI Gene ID:3171
NCBI Accession:BC016024
UniProt Secondary Accession:P55318,Q53F16, Q9UMW9, A9LYI5,
UniProt Related Accession:P55318
Molecular Weight:37,140 Da
NCBI Full Name:Homo sapiens forkhead box A3, mRNA
NCBI Synonym Full Names:forkhead box A3
NCBI Official Symbol:FOXA3  
NCBI Official Synonym Symbols:FKHH3; HNF3G; TCF3G  
NCBI Protein Information:hepatocyte nuclear factor 3-gamma
UniProt Protein Name:Hepatocyte nuclear factor 3-gamma
UniProt Synonym Protein Names:Fork head-related protein FKH H3; Forkhead box protein A3; Transcription factor 3G; TCF-3G
Protein Family:Hepatocyte nuclear factor
UniProt Gene Name:FOXA3  
UniProt Entry Name:FOXA3_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products