Cell Biology Antibodies 13

Anti-FOLH1 Antibody (CAB17485)

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SKU:
CAB17485
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FOLH1 Antibody
Antibody SKU:CAB17485
Antibody Size:20uL, 50 uL
Application:IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 45-290 of human FOLH1 (NP_001014986.1).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 45-290 of human FOLH1 (NP_001014986.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SSNE ATNI TPKH NMKA FLDE LKAE NIKK FLYN FTQI PHLA GTEQ NFQL AKQI QSQW KEFG LDSV ELAH YDVL LSYP NKTH PNYI SIIN EDGN EIFN TSLF EPPP PGYE NVSD IVPP FSAF SPQG MPEG DLVY VNYA RTED FFKL ERDM KINC SGKI VIAR YGKV FRGN KVKN AQLA GAKG VILY SDPA DYFA PGVK SYPD GWNL PGGG VQRG NILN LNGA GDPL TPGY PANE YAYR RGIA EAVG LP
Gene ID:2346
Uniprot:Q04609
Cellular Location:
Calculated MW:9kDa/12kDa/50kDa/78kDa/80kDa/82kDa/84kDa
Observed MW:Refer to figures
Synonyms:FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP, FOLH1
Background:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
UniProt Protein Function:FOLH1: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Belongs to the peptidase M28 family. M28B subfamily. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; EC 3.4.17.21; Protease

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: membrane; integral to plasma membrane; cytoplasm

Molecular Function:peptidase activity; dipeptidase activity; metallopeptidase activity; carboxypeptidase activity; metal ion binding

Biological Process: folic acid and derivative metabolic process; proteolysis

NCBI Summary:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
UniProt Code:Q04609
NCBI GenInfo Identifier:548615
NCBI Gene ID:2346
NCBI Accession:Q04609.1
UniProt Secondary Accession:Q04609,O43748, Q16305, Q541A4, Q8TAY3, Q9NP15, A4UU12 A9CB79, B7Z312, B7Z343, D3DQS5, E9PDX8,
UniProt Related Accession:Q04609
Molecular Weight:84kDa
NCBI Full Name:Glutamate carboxypeptidase 2
NCBI Synonym Full Names:folate hydrolase (prostate-specific membrane antigen) 1
NCBI Official Symbol:FOLH1  
NCBI Official Synonym Symbols:PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase  
NCBI Protein Information:glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen
UniProt Protein Name:Glutamate carboxypeptidase 2
UniProt Synonym Protein Names:Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Membrane glutamate carboxypeptidase; mGCP; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; PSM; PSMA; Pteroylpoly-gamma-glutamate carboxypeptidase
UniProt Gene Name:FOLH1  
UniProt Entry Name:FOLH1_HUMAN
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