Cardiovascular Antibodies

Anti-FGG Antibody (CAB5642)

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SKU:
CAB5642
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular

Description

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Antibody Name:Anti-FGG Antibody
Antibody SKU:CAB5642
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-330 of human FGG (NP_000500.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-330 of human FGG (NP_000500.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GIAD FLST YQTK VDKD LQSL EDIL HQVE NKTS EVKQ LIKA IQLT YNPD ESSK PNMI DAAT LKSR KMLE EIMK YEAS ILTH DSSI RYLQ EIYN SNNQ KIVN LKEK VAQL EAQC QEPC KDTV QIHD ITGK DCQD IANK GAKQ SGLY FIKP LKAN QQFL VYCE IDGS GNGW TVFQ KRLD GSVD FKKN WIQY KEGF GHLS PTGT TEFW LGNE KIHL ISTQ SAIP YALR VELE DWNG RTST ADYA MFKV GPEA DKYR LTYA YFAG GDAG DAFD GFDF GDDP SDKF F
Gene ID:2266
Uniprot:P02679
Cellular Location:Secreted
Calculated MW:49kDa/51kDa
Observed MW:52kDa
Synonyms:FGG
Background:The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms.
UniProt Protein Function:FGG: Fibrinogen has a double Function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q28

Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region; plasma membrane; cell cortex; external side of plasma membrane

Molecular Function:protein binding, bridging; metal ion binding; cell adhesion molecule binding; structural molecule activity; receptor binding

Biological Process: protein polymerization; platelet activation; extracellular matrix organization and biogenesis; positive regulation of heterotypic cell-cell adhesion; platelet degranulation; cellular protein complex assembly; positive regulation of protein secretion; cell-matrix adhesion; positive regulation of vasoconstriction; response to calcium ion; blood coagulation; signal transduction; positive regulation of exocytosis

Disease: Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital

NCBI Summary:The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P02679
NCBI GenInfo Identifier:20178280
NCBI Gene ID:2266
NCBI Accession:P02679.3
UniProt Secondary Accession:P02679,P04469, P04470, Q53Y18, Q96A14, Q96KJ3, Q9UC62 Q9UC63, Q9UCF3, A8K057,
UniProt Related Accession:P02679
Molecular Weight:49,497 Da
NCBI Full Name:Fibrinogen gamma chain
NCBI Synonym Full Names:fibrinogen gamma chain
NCBI Official Symbol:FGG  
NCBI Protein Information:fibrinogen gamma chain; fibrinogen, gamma polypeptide
UniProt Protein Name:Fibrinogen gamma chain
Protein Family:Fibrinogen
UniProt Gene Name:FGG  
UniProt Entry Name:FIBG_HUMAN
Anti-FGG Antibody (CAB5642)Western blot analysis of extracts of Mouse liver, using FGG Rabbit pAb (CAB5642) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020).
Anti-FGG Antibody (CAB5642)Immunofluorescence analysis of NIH/3T3 cells using FGG antibody (CAB5642) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-FGG Antibody (CAB5642)Immunofluorescence analysis of U-2 OS cells using FGG antibody (CAB5642) at dilution of 1:100. Blue: DAPI for nuclear staining.
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