Cell Biology Antibodies 13

Anti-FGFR1OP Antibody (CAB17627)

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SKU:
CAB17627
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FGFR1OP Antibody
Antibody SKU:CAB17627
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human FGFR1OP (NP_919410.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse kidney, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human FGFR1OP (NP_919410.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAT AAAV VAEE DTEL RDLL VQTL ENSG VLNR IKAE LRAA VFLA LEEQ EKVE NKTP LVNE SLKK FLNT KD
Gene ID:11116
Uniprot:O95684
Cellular Location:
Calculated MW:16kDa/40kDa/43kDa
Observed MW:43kDa
Anti-FGFR1OP Antibody (CAB17627)Western blot - FGFR1OP Polyclonal Antibody (CAB17627)
Synonyms:FGFR1OP, FOP
Background:This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
UniProt Protein Function:FOP: Required for anchoring microtubules to the centrosomes. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity. Belongs to the FGFR1OP family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: centrosome; cytosol; nucleus; perinuclear region of cytoplasm

Molecular Function:protein binding; protein homodimerization activity; protein kinase binding; protein tyrosine kinase inhibitor activity; protein-tyrosine kinase activity

Biological Process: G2/M transition of mitotic cell cycle; negative regulation of protein kinase activity; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation

NCBI Summary:This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
UniProt Code:O95684
NCBI GenInfo Identifier:74762130
NCBI Gene ID:11116
NCBI Accession:O95684.1
UniProt Secondary Accession:O95684,Q49AI0, Q5R3F6, Q96EW1, A8K1D1, B2R705,
UniProt Related Accession:O95684
Molecular Weight:16,106 Da
NCBI Full Name:FGFR1 oncogene partner
NCBI Synonym Full Names:FGFR1 oncogene partner
NCBI Official Symbol:FGFR1OP  
NCBI Official Synonym Symbols:FOP  
NCBI Protein Information:FGFR1 oncogene partner
UniProt Protein Name:FGFR1 oncogene partner
Protein Family:FGFR1 oncogene partner
UniProt Gene Name:FGFR1OP  
UniProt Entry Name:FR1OP_HUMAN
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