Cell Biology Antibodies 7

Anti-FGD1 Antibody (CAB16709)

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SKU:
CAB16709
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FGD1 Antibody
Antibody SKU:CAB16709
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FGD1 (NP_004454.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:mouse brain, mouse heart, rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FGD1 (NP_004454.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLNS TNRE DEDT PPNS PNVD LGKR APTP IREK EVTM CMRC QEPF NSIT KRRH HCKA CGHV VCGK CSEF RARL VYDN NRSN RVCT DCYV ALHG VPGS SPAC S
Gene ID:2245
Uniprot:P98174
Cellular Location:Cell projection, Cytoplasm, cytoskeleton, lamellipodium, ruffle
Calculated MW:106kDa
Observed MW:110kDa
Synonyms:FGD1, AAS, FGDY, MRXS16, ZFYVE3, FYVE
Background:This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.
NCBI Summary:This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability. [provided by RefSeq, Jul 2017]
UniProt Code:P98174
NCBI GenInfo Identifier:24797153
NCBI Gene ID:2245
NCBI Accession:NP_004454
UniProt Related Accession:P98174
Molecular Weight:106kDa
NCBI Full Name:FYVE, RhoGEF and PH domain-containing protein 1
NCBI Synonym Full Names:FYVE, RhoGEF and PH domain containing 1
NCBI Official Symbol:FGD1  
NCBI Official Synonym Symbols:AAS; FGDY; MRXS16; ZFYVE3  
NCBI Protein Information:FYVE, RhoGEF and PH domain-containing protein 1
UniProt Protein Name:FYVE, RhoGEF and PH domain-containing protein 1
UniProt Synonym Protein Names:Faciogenital dysplasia 1 protein; Rho/Rac guanine nucleotide exchange factor FGD1; Rho/Rac GEF; Zinc finger FYVE domain-containing protein 3
Protein Family:FYVE, RhoGEF and PH domain-containing protein
UniProt Gene Name:FGD1  
UniProt Entry Name:FGD1_HUMAN
Anti-FGD1 Antibody (CAB16709)Western blot analysis of extracts of various cell lines, using FGD1 antibody (CAB16709) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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