Cell Biology Antibodies 12
Anti-FCGRT Antibody (CAB8544)
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- SKU:
- CAB8544
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FCGRT Antibody |
| Antibody SKU: | CAB8544 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human FCGRT (NP_004098.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human FCGRT (NP_004098.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ESHL SLLY HLTA VSSP APGT PAFW VSGW LGPQ QYLS YNSL RGEA EPCG AWVW ENQV SWYW EKET TDLR IKEK LFLE AFKA LGGK GPYT LQGL LGCE LGPD NTSV PTAK FALN GEEF MNFD LKQG TWGG DWPE ALAI SQRW QQQD KAAN KELT FLLF SCPH RLRE HLER GRGN LEWK EPPS MRLK ARPS SPGF SVLT CSAF SFYP PELQ LRFL RNGL AAGT GQGD FGPN SDGS FHAS SSLT VKSG DEHH YCCI VQHA GLAQ PLRV ELES PAKS SVLV |
| Gene ID: | 2217 |
| Uniprot: | P55899 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 39kDa |
| Observed MW: | 40kDa |
| Synonyms: | FCGRT, FCRN, alpha-chain |
| Background: | This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | FCGRT: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. Belongs to the immunoglobulin superfamily. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: plasma membrane Molecular Function:antigen binding; beta-2-microglobulin binding; IgG binding; IgG receptor activity; peptide antigen binding Biological Process: antigen processing and presentation |
| NCBI Summary: | This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] |
| UniProt Code: | P55899 |
| NCBI GenInfo Identifier: | 2497331 |
| NCBI Gene ID: | 2217 |
| NCBI Accession: | P55899.1 |
| UniProt Secondary Accession: | P55899,Q5HYM5, Q9HBV7, Q9NZ19, |
| UniProt Related Accession: | P55899 |
| Molecular Weight: | 39,743 Da |
| NCBI Full Name: | IgG receptor FcRn large subunit p51 |
| NCBI Synonym Full Names: | Fc fragment of IgG receptor and transporter |
| NCBI Official Symbol: | FCGRT |
| NCBI Official Synonym Symbols: | FCRN; alpha-chain |
| NCBI Protein Information: | IgG receptor FcRn large subunit p51 |
| UniProt Protein Name: | IgG receptor FcRn large subunit p51 |
| UniProt Synonym Protein Names: | IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor |
| Protein Family: | IgG receptor |
| UniProt Gene Name: | FCGRT |
| UniProt Entry Name: | FCGRN_HUMAN |
 | Western blot analysis of extracts of HL-60 cells, using FCGRT antibody (CAB8544) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of C6 cells using FCGRT Rabbit pAb (CAB8544) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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