Cell Biology Antibodies 4
Anti-FCGR3B Antibody (CAB13980)
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- SKU:
- CAB13980
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FCGR3B Antibody |
| Antibody SKU: | CAB13980 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FCGR3B (NP_000561.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | THP-1, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FCGR3B (NP_000561.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MWQL LLPT ALLL LVSA GMRT EDLP KAVV FLEP QWYS VLEK DSVT LKCQ GAYS PEDN STQW FHNE NLIS SQAS SYFI DAAT VNDS GEYR CQTN LSTL SDPV QLEV HIGW LLLQ APRW VFKE EDPI HLRC HSWK NTAL HKVT YLQN GKDR KYFH HNSD FHIP KATL KDSG SYFC RGLV GSKN VSSE TVNI TITQ GLAV STIS SFSP PGYQ VSFC LVMV LLFA VDTG LYFS VKTN I |
| Gene ID: | 2215 |
| Uniprot: | O75015 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor, Secreted |
| Calculated MW: | 26kDa |
| Observed MW: | 50kDa |
| Synonyms: | FCGR3B, CD16, CD16b, FCG3, FCGR3, FCR-10, FCRIII, FCRIIIb |
| Background: | The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. |
| UniProt Protein Function: | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| NCBI Summary: | The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012] |
| UniProt Code: | O75015 |
| NCBI GenInfo Identifier: | 7994572 |
| NCBI Gene ID: | 2215 |
| NCBI Accession: | O75015.2 |
| UniProt Related Accession: | O75015 |
| Molecular Weight: | |
| NCBI Full Name: | Low affinity immunoglobulin gamma Fc region receptor III-B |
| NCBI Synonym Full Names: | Fc fragment of IgG receptor IIIb |
| NCBI Official Symbol: | FCGR3B |
| NCBI Official Synonym Symbols: | CD16; FCG3; CD16A; CD16b; FCGR3; FCGR3A; FCR-10; FCRIII; FCRIIIb |
| NCBI Protein Information: | low affinity immunoglobulin gamma Fc region receptor III-B |
| UniProt Protein Name: | Low affinity immunoglobulin gamma Fc region receptor III-B |
| UniProt Synonym Protein Names: | Fc-gamma RIII-beta; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb; FcR-10; IgG Fc receptor III-1; CD_antigen: CD16b |
| UniProt Gene Name: | FCGR3B |
 | Western blot analysis of extracts of various cell lines, using FCGR3B antibody (CAB13980) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
 | Immunofluorescence analysis of U2OS cells using FCGR3B antibody (CAB13980) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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