Immunology Antibodies 1

Anti-FBXO38 Antibody (CAB10328)

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SKU:
CAB10328
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-FBXO38 Antibody
Antibody SKU:CAB10328
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human FBXO38
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:HeLa
Immunogen:Recombinant protein of human FBXO38
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:81545
Uniprot:Q6PIJ6
Cellular Location:Cytoplasm, Nucleus
Calculated MW:210KDa
Observed MW:210kDa
Synonyms:FBXO38, Fbx38, HMN2D, MOKA, SP329
Background:This gene encodes a large protein that contains an F-box domain and may participate in protein ubiquitination. The encoded protein is a transcriptional co-activator of Krueppel-like factor 7 (Klf7). A heterozygous mutation in this gene was found in individuals with autosomal dominant distal hereditary motor neuronopathy type IID. There is a pseudogene for this gene on chromosome 4. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:FBX38: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q32

Disease: Neuronopathy, Distal Hereditary Motor, Type Iid

NCBI Summary:This gene encodes a large protein that contains an F-box domain and may participate in protein ubiquitination. The encoded protein is a transcriptional co-activator of Krueppel-like factor 7 (Klf7). A heterozygous mutation in this gene was found in individuals with autosomal dominant distal hereditary motor neuronopathy type IID. There is a pseudogene for this gene on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
UniProt Code:Q6PIJ6
NCBI GenInfo Identifier:116241362
NCBI Gene ID:81545
NCBI Accession:Q6PIJ6.3
UniProt Secondary Accession:Q6PIJ6,Q6PK72, Q7Z2U0, Q86VN3, Q9BXY6, Q9H837, Q9HC40
UniProt Related Accession:Q6PIJ6
Molecular Weight:134kDa
NCBI Full Name:F-box only protein 38
NCBI Synonym Full Names:F-box protein 38
NCBI Official Symbol:FBXO38  
NCBI Official Synonym Symbols:MOKA; Fbx38; HMN2D; SP329  
NCBI Protein Information:F-box only protein 38
UniProt Protein Name:F-box only protein 38
UniProt Synonym Protein Names:Modulator of KLF7 activity homolog; MoKA
Protein Family:F-box only protein
UniProt Gene Name:FBXO38  
Anti-FBXO38 Antibody (CAB10328)Western blot analysis of extracts of HeLa cells, using FBXO38 Rabbit pAb (CAB10328) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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