Epigenetics & Nuclear Signaling Antibodies 4
Anti-FANCE Antibody (CAB8417)
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- SKU:
- CAB8417
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-FANCE Antibody |
| Antibody SKU: | CAB8417 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human FANCE (NP_068741.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human FANCE (NP_068741.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATP DAGL PGAE GVEP APWA QLEA PARL LLQA LQAG PEGA RRGL GVLR ALGS RGWE PFDW GRLL EALC REEP VVQG PDGR LELK PLLL RLPR ICQR NLMS LLMA VRPS LPES GLLS VLQI AQQD LAPD PDAW LRAL GELL RRDL GVGT SMEG ASPL SERC QRQL QSLC RGLG LGGR RLKS PQAP DPEE EENR DSQQ PGKR RKDS EEEA ASPE GKRV PKRL RCWE EEED HEKE RPEH KSLE SLAD GGSA SPIK DQP |
| Gene ID: | 2178 |
| Uniprot: | Q9HB96 |
| Cellular Location: | Nucleus |
| Calculated MW: | 58kDa |
| Observed MW: | 80kDa |
| Synonyms: | FANCE, FACE, FAE |
| Background: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. |
| UniProt Protein Function: | FANCE: As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. Interacts with FANCC and FANCD2. |
| UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 6p22-p21 Cellular Component: nucleoplasm; nucleus Disease: Fanconi Anemia, Complementation Group E; Tracheoesophageal Fistula With Or Without Esophageal Atresia |
| NCBI Summary: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HB96 |
| NCBI GenInfo Identifier: | 11345454 |
| NCBI Gene ID: | 2178 |
| NCBI Accession: | NP_068741.1 |
| UniProt Secondary Accession: | Q9HB96,Q4ZGH2, A8K907, |
| UniProt Related Accession: | Q9HB96 |
| Molecular Weight: | 58,711 Da |
| NCBI Full Name: | Fanconi anemia group E protein |
| NCBI Synonym Full Names: | Fanconi anemia complementation group E |
| NCBI Official Symbol: | FANCE |
| NCBI Official Synonym Symbols: | FAE; FACE |
| NCBI Protein Information: | Fanconi anemia group E protein |
| UniProt Protein Name: | Fanconi anemia group E protein |
| Protein Family: | Fanconi anemia group E protein |
| UniProt Gene Name: | FANCE |
| UniProt Entry Name: | FANCE_HUMAN |
 | Western blot analysis of extracts of mouse thymus, using FANCE antibody (CAB8417) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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