Immunology Antibodies 2

Anti-FAIM3 Antibody (CAB6320)

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SKU:
CAB6320
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-FAIM3 Antibody
Antibody SKU:CAB6320
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human FAIM3 (NP_005440.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, U-251MG, SW480
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human FAIM3 (NP_005440.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RILP EVKV EGEL GGSV TIKC PLPE MHVR IYLC REMA GSGT CGTV VSTT NFIK AEYK GRVT LKQY PRKN LFLV EVTQ LTES DSGV YACG AGMN TDRG KTQK VTLN VHSE YEPS WEEQ PMPE TPKW FHLP YLFQ MPAY ASSS KFVT RVTT PAQR GKVP PVHH SSPT TQIT HRPR VSRA SSVA GDKP RTFL PSTT ASKI SALE GLLK PQTP SYNH HTRL HRQR ALDY GSQS GREG QG
Gene ID:9214
Uniprot:O60667
Cellular Location:Membrane, Secreted, Single-pass membrane protein
Calculated MW:31kDa/33kDa/43kDa
Observed MW:40kDa
Synonyms:FCMR, FAIM3, TOSO
Background:
UniProt Protein Function:FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; integral to membrane

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis

NCBI Summary:Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
UniProt Code:O60667
NCBI GenInfo Identifier:74754378
NCBI Gene ID:9214
NCBI Accession:O60667.1
UniProt Related Accession:O60667
Molecular Weight:
NCBI Full Name:Fas apoptotic inhibitory molecule 3
NCBI Synonym Full Names:Fc fragment of IgM receptor
NCBI Official Symbol:FCMR  
NCBI Official Synonym Symbols:TOSO; FAIM3  
NCBI Protein Information:fas apoptotic inhibitory molecule 3
UniProt Protein Name:Fas apoptotic inhibitory molecule 3
UniProt Synonym Protein Names:Regulator of Fas-induced apoptosis Toso
Protein Family:Fas apoptotic inhibitory molecule
UniProt Gene Name:FAIM3  
UniProt Entry Name:FAIM3_HUMAN
Anti-FAIM3 Antibody (CAB6320)Western blot analysis of extracts of various cell lines, using FAIM3 antibody (CAB6320) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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