Name: Anti-ETV7 Antibody (CAB6255)
Brand: Epigenetics & Nuclear Signaling Antibodies 2
SKU: CAB6255
Availability: OutOfStock

Antibody Name:	Anti-ETV7 Antibody
Antibody SKU:	CAB6255
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human ETV7 (NP_057219.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	U-937, A-431, U-251MG, HeLa

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human ETV7 (NP_057219.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MQEG ELAI SPIS PVAA MPPL GTHV QARC EAQI NLLG EGGI CKLP GRLR IQPA LWSR EDVL HWLR WAEQ EYSL PCTA EHGF EMNG RALC ILTK DDFR HRAP SSGD VLYE LLQY IKTQ RRAL VCGP FFGG IFRL KTPT QHSP VPPE EVTG PSQM DTRR GHLL QPPD PGLT SNFG HLDD PGLA RWTP GKEE SLNL CHCA ELGC RTQG VCSF PA
Gene ID:	51513
Uniprot:	Q9Y603
Cellular Location:	Nucleus
Calculated MW:	22kDa/29kDa/30kDa/32kDa/36kDa/38kDa
Observed MW:	37kDa

Synonyms:

ETV7, TEL-2, TEL2, TELB

Background:

The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).

UniProt Protein Function:	ETV7: Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity. Belongs to the ETS family. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p21 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; negative regulation of transcription from RNA polymerase II promoter; cell differentiation
NCBI Summary:	The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011]
UniProt Code:	Q9Y603
NCBI GenInfo Identifier:	13124589
NCBI Gene ID:	51513
NCBI Accession:	Q9Y603.1
UniProt Secondary Accession:	Q9Y603,Q5R3L3, Q5R3L4, Q9NZ65, Q9NZ66, Q9NZ68, Q9NZR8 Q9UNJ7, Q9Y5K4, B3KVC2, B4DVB6, B4E1G4,
UniProt Related Accession:	Q9Y603
Molecular Weight:	341
NCBI Full Name:	Transcription factor ETV7
NCBI Synonym Full Names:	ets variant 7
NCBI Official Symbol:	ETV7
NCBI Official Synonym Symbols:	TEL2; TELB; TEL-2
NCBI Protein Information:	transcription factor ETV7; TEL2 oncogene; tel-related Ets factor; ETS-related protein Tel2; ETS translocation variant 7; Ets transcription factor TEL-2b; ets variant gene 7 (TEL2 oncogene)
UniProt Protein Name:	Transcription factor ETV7
UniProt Synonym Protein Names:	ETS translocation variant 7; ETS-related protein Tel2; Tel-related Ets factor; Transcription factor Tel-2
Protein Family:	Transcription factor
UniProt Gene Name:	ETV7
UniProt Entry Name:	ETV7_HUMAN

Western blot analysis of extracts of various cell lines, using ETV7 antibody (CAB6255) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

Antibodies

Anti-ETV7 Antibody (CAB6794)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)