Epigenetics & Nuclear Signaling Antibodies 2
Anti-ETV6 Antibody (CAB1637)
(No reviews yet)
Write a Review
- SKU:
- CAB1637
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ETV6 Antibody |
| Antibody SKU: | CAB1637 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1). |
| Application: | WB IHC IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse spleen, Mouse lung, Rat spleen, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSET PAQC SIKQ ERIS YTPP ESPV PSYA SSTP LHVP VPRA LRME EDSI RLPA HLRL QPIY WSRD DVAQ WLKW AENE FSLR PIDS NTFE MNGK ALLL LTKE DFRY RSPH SGDV LYEL LQHI LKQR KPRI LFSP FFHP GNSI HTQP EVIL HQNH EEDN CVQR TPRP SVDN VHHN PPTI ELLH RSRS PITT NHRP SPDP EQRP LRSP LDNM IRRL SPAE RAQG PRPH QENN HQES YPLS VSPM ENNH CPAS SESH PKPS SPRQ ESTR VIQL MPSP IMHP LILN PRHS VDFK QSRL SEDG LHRE |
| Gene ID: | 2120 |
| Uniprot: | P41212 |
| Cellular Location: | Nucleus |
| Calculated MW: | 53kDa |
| Observed MW: | 53kDa |
| Synonyms: | ETV6, TEL, TEL/ABL, THC5 |
| Background: | This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. |
| UniProt Protein Function: | Tel: Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2. Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE). A hematologic disorder characterized by malignant eosinophils proliferation. A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5. Belongs to the ETS family. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 12p13 Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function:protein binding; protein domain specific binding; transcription factor activity Biological Process: cell differentiation; negative regulation of transcription from RNA polymerase II promoter Disease: Thrombocytopenia 5 |
| NCBI Summary: | This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P41212 |
| NCBI GenInfo Identifier: | 730927 |
| NCBI Gene ID: | 2120 |
| NCBI Accession: | P41212.1 |
| UniProt Secondary Accession: | P41212,Q9UMF6, Q9UMF7, Q9UMG0, A3QVP6, A8K076, |
| UniProt Related Accession: | P41212 |
| Molecular Weight: | 53,000 Da |
| NCBI Full Name: | Transcription factor ETV6 |
| NCBI Synonym Full Names: | ETS variant 6 |
| NCBI Official Symbol: | ETV6 |
| NCBI Official Synonym Symbols: | TEL; THC5; TEL/ABL |
| NCBI Protein Information: | transcription factor ETV6 |
| UniProt Protein Name: | Transcription factor ETV6 |
| UniProt Synonym Protein Names: | ETS translocation variant 6; ETS-related protein Tel1; Tel |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | ETV6 |
| UniProt Entry Name: | ETV6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ETV6 antibody (CAB1637) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunoprecipitation analysis of 200ug extracts of SW620 cells using 3ug ETV6 antibody (CAB1637). Western blot was performed from the immunoprecipitate using ETV6 antibody (CAB1637) at a dilition of 1:500. |
View AllClose
Related Products
