Immunology Antibodies 2
Anti-ETS1 Antibody (CAB15666)
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- SKU:
- CAB15666
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-ETS1 Antibody |
| Antibody SKU: | CAB15666 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ETS1 (NP_005229.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ETS1 (NP_005229.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKAA VDLK PTLT IIKT EKVD LELF PSPD MECA DVPL LTPS SKEM MSQA LKAT FSGF TKEQ QRLG IPKD PRQW TETH VRDW VMWA VNEF SLKG VDFQ KFCM NGAA LCAL GKDC FLEL APDF VGDI LWEH LEIL QKED VKPY QVNG VNPA YPES RYTS DYFI SYGI EHAQ CVPP SEFS EPSF ITES YQTL HPIS SEEL LSLK YEND YPSV ILRD PLQT DTLQ NDYF AIKQ EVVT PDNM CMGR TSRG KLGG QDSF ESIE SYDS |
| Gene ID: | 2113 |
| Uniprot: | P14921 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 25kDa/30kDa/40kDa/50kDa/55kDa |
| Observed MW: | 50KDa |
| Synonyms: | ETS-1, EWSR2, c-ets-1, p54, ETS1 |
| Background: | This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | Ets-1: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus oncogene. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. It contributes to the regulation of cellular differentiation in hematopoietic cells. Ets1 promotes invasive behavior in endothelial cells, vascular smooth muscle cells and epithelial cancer cells. Regulates the expression of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGFR gene expression. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; identical protein binding; protein binding; transcription factor activity Biological Process: cell motility involved in cell locomotion; immune response; negative regulation of cell proliferation; PML body organization and biogenesis; positive regulation of cell motility; positive regulation of erythrocyte differentiation; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of angiogenesis |
| NCBI Summary: | This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | P14921 |
| NCBI GenInfo Identifier: | 119641 |
| NCBI Gene ID: | 2113 |
| NCBI Accession: | P14921.1 |
| UniProt Secondary Accession: | P14921,Q14278, Q16080, Q6N087, Q96AC5, A9UL17, F5GYX9 |
| UniProt Related Accession: | P14921 |
| Molecular Weight: | 30,860 Da |
| NCBI Full Name: | Protein C-ets-1 |
| NCBI Synonym Full Names: | ETS proto-oncogene 1, transcription factor |
| NCBI Official Symbol: | ETS1 |
| NCBI Official Synonym Symbols: | p54; ETS-1; EWSR2; c-ets-1 |
| NCBI Protein Information: | protein C-ets-1 |
| UniProt Protein Name: | Protein C-ets-1 |
| UniProt Synonym Protein Names: | p54 |
| Protein Family: | Protein |
| UniProt Gene Name: | ETS1 |
| UniProt Entry Name: | ETS1_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using ETS1 antibody (CAB15666) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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