Cell Biology Antibodies 1
Anti-ERVFRD-1 Antibody (CAB10162)
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- SKU:
- CAB10162
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ERVFRD-1 Antibody |
| Antibody SKU: | CAB10162 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 16-250 of human ERVFRD-1 (NP_997465.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:4000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, HT-29, 293T, A-549, K-562, 22Rv1, A375, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 16-250 of human ERVFRD-1 (NP_997465.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AYRH PDFP LLEK AQQL LQST GSPY STNC WLCT SSST ETPG TAYP ASPR EWTS IEAE LHIS YRWD PNLK GLMR PANS LLST VKQD FPDI RQKP PIFG PIFT NINL MGIA PICV MAKR KNGT NVGT LPST VCNV TFTV DSNQ QTYQ TYTH NQFR HQPR FPKP PNIT FPQG TLLD KSSR FCQG RPSS CSTR NFWF RPAD YNQC LQIS NLSS TAEW VLLD QTRN SLFW ENKT KGAN QSQ |
| Gene ID: | 405754 |
| Uniprot: | P60508 |
| Cellular Location: | Cell membrane, Single-pass membrane protein, Virion |
| Calculated MW: | 59kDa |
| Observed MW: | 38kDa |
| Synonyms: | ERVFRD-1, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD |
| Background: | Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. |
| UniProt Protein Function: | ERVFRDE1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. Can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p24.1 Biological Process: syncytium formation |
| NCBI Summary: | Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012] |
| UniProt Code: | P60508 |
| NCBI GenInfo Identifier: | 44887864 |
| NCBI Gene ID: | 405754 |
| NCBI Accession: | P60508.1 |
| UniProt Related Accession: | P60508 |
| Molecular Weight: | 59,523 Da |
| NCBI Full Name: | Syncytin-2 |
| NCBI Synonym Full Names: | endogenous retrovirus group FRD member 1 |
| NCBI Official Symbol: | ERVFRD-1 |
| NCBI Official Synonym Symbols: | envFRD; UNQ6191; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD |
| NCBI Protein Information: | syncytin-2 |
| UniProt Protein Name: | Syncytin-2 |
| UniProt Synonym Protein Names: | Endogenous retrovirus group FRD member 1; Envelope polyprotein; HERV-FRD; HERV-FRD_6p24.1 provirus ancestral Env polyprotein |
| Protein Family: | Syncytin |
| UniProt Gene Name: | ERVFRD-1 |
| UniProt Entry Name: | SYCY2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ERVFRD-1 antibody (CAB10162) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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