Cell Biology Antibodies 4
Anti-ERBB3 Antibody (CAB13976)
- SKU:
- CAB13976
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ERBB3 Antibody |
| Antibody SKU: | CAB13976 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-285 of human ERBB3 (NP_001973.2). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-285 of human ERBB3 (NP_001973.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SEVG NSQA VCPG TLNG LSVT GDAE NQYQ TLYK LYER CEVV MGNL EIVL TGHN ADLS FLQW IREV TGYV LVAM NEFS TLPL PNLR VVRG TQVY DGKF AIFV MLNY NTNS SHAL RQLR LTQL TEIL SGGV YIEK NDKL CHMD TIDW RDIV RDRD AEIV VKDN GRSC PPCH EVCK GRCW GPGS EDCQ TLTK TICA PQCN GHCF GPNP NQCC HDEC AGGC SGPQ DTDC FACR HFND SGAC VPRC PQPL VYNK LTFQ LEPN PHTK YQYG GV |
| Gene ID: | 2065 |
| Uniprot: | P21860 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 20kDa/36kDa/77kDa/141kDa/148kDa |
| Observed MW: |
| Synonyms: | ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3 |
| Background: | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. |
| UniProt Protein Function: | HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Oncoprotein; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; EC 2.7.10.1; TK group; EGFR family Chromosomal Location of Human Ortholog: 12q13 Cellular Component: extracellular space; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; receptor complex; lateral plasma membrane Molecular Function:identical protein binding; protein binding; transmembrane receptor activity; protein homodimerization activity; protein heterodimerization activity; protein-tyrosine kinase activity; growth factor binding; protein tyrosine kinase activator activity; ATP binding Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide 3-kinase cascade; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; wound healing; heart development; cranial nerve development; negative regulation of cell adhesion; signal transduction; protein amino acid phosphorylation; peripheral nervous system development; negative regulation of signal transduction; regulation of cell proliferation; Schwann cell differentiation; positive regulation of phosphoinositide 3-kinase cascade; neuron apoptosis; innate immune response; negative regulation of secretion; negative regulation of neuron apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway Disease: Lethal Congenital Contracture Syndrome 2 |
| NCBI Summary: | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P21860 |
| NCBI GenInfo Identifier: | 54792102 |
| NCBI Gene ID: | 2065 |
| NCBI Accession: | NP_001005915.1 |
| UniProt Secondary Accession: | P21860,Q9BUD7, A8K6L6, B4DIK7, B4DV32, E9PDT8, |
| UniProt Related Accession: | P21860 |
| Molecular Weight: | 148,098 Da |
| NCBI Full Name: | receptor tyrosine-protein kinase erbB-3 isoform s |
| NCBI Synonym Full Names: | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) |
| NCBI Official Symbol: | ERBB3 |
| NCBI Official Synonym Symbols: | HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3 |
| NCBI Protein Information: | receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3 |
| UniProt Protein Name: | Receptor tyrosine-protein kinase erbB-3 |
| UniProt Synonym Protein Names: | Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3 |
| Protein Family: | Receptor tyrosine-protein kinase |
| UniProt Gene Name: | ERBB3 |
| UniProt Entry Name: | ERBB3_HUMAN |
 | Immunohistochemistry of paraffin-embedded rat brain using ERBB3 Antibody (CAB13976) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using ERBB3 Antibody (CAB13976) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using ERBB3 Antibody (CAB13976) at dilution of 1:100 (40x lens). |
Related Products
Phospho-ErbB3/HER3-Y1289 Polyclonal Antibody
