Developmental Biology
Anti-ELAVL3 Antibody (CAB6091)
- SKU:
- CAB6091
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-ELAVL3 Antibody |
| Antibody SKU: | CAB6091 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ELAVL3 (NP_001411.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse spinal cord, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ELAVL3 (NP_001411.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVTQ ILGA MESQ VGGG PAGP ALPN GPLL GTNG ATDD SKTN LIVN YLPQ NMTQ DEFK SLFG SIGD IESC KLVR DKIT GQSL GYGF VNYS DPND ADKA INTL |
| Gene ID: | 1995 |
| Uniprot: | Q14576 |
| Cellular Location: | |
| Calculated MW: | 38kDa/39kDa |
| Observed MW: | 37kDa |
| Synonyms: | ELAVL3, HUC, HUCL, PLE21 |
| Background: | A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| UniProt Protein Function: | ELAVL3: Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19p13.2 Molecular Function:AU-rich element binding |
| NCBI Summary: | A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14576 |
| NCBI GenInfo Identifier: | 21264436 |
| NCBI Gene ID: | 1995 |
| NCBI Accession: | Q14576.3 |
| UniProt Secondary Accession: | Q14576,Q16135, Q96CL8, Q96QS9, |
| UniProt Related Accession: | Q14576 |
| Molecular Weight: | 38,865 Da |
| NCBI Full Name: | ELAV-like protein 3 |
| NCBI Synonym Full Names: | ELAV like neuron-specific RNA binding protein 3 |
| NCBI Official Symbol: | ELAVL3 |
| NCBI Official Synonym Symbols: | HUC; HUCL; PLE21 |
| NCBI Protein Information: | ELAV-like protein 3 |
| UniProt Protein Name: | ELAV-like protein 3 |
| UniProt Synonym Protein Names: | Hu-antigen C; HuC; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic limbic encephalitis antigen 21 |
| Protein Family: | ELAV-like protein |
| UniProt Gene Name: | ELAVL3 |
| UniProt Entry Name: | ELAV3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ELAVL3 antibody (CAB6091) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat brain using ELAVL3 antibody (CAB6091) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using ELAVL3 antibody (CAB6091) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of SH-SY5Y cells using ELAVL3 Rabbit pAb (CAB6091) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of rat brain using ELAVL3 Rabbit pAb (CAB6091) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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