Epigenetics & Nuclear Signaling Antibodies 5

Anti-eIF5A Antibody (CAB4414)

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SKU:
CAB4414
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
EIF-5A
Synonyms:
EIF5A1
Synonyms:
eIF5AI
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:eIF5A Rabbit mAb
Product Code:CAB4414
Size:20uL, 50uL, 100uL
Synonyms:EIF-5A, EIF5A1, eIF5AI
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human eIF5A
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Jurkat, HUVEC, Mouse testis, Mouse pancreas, Rat lung, Rat testis, Rat spleen
Immunogen:A synthesized peptide derived from human eIF5A
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1984
Uniprot:P63241
Cellular Location:Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Nucleus, Peripheral membrane protein, nuclear pore complex
Calculated MW:18kDa
Observed MW:18KDa
UniProt Protein Function:EIF5A: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. Belongs to the eIF-5A family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Translation initiation; Translation

Chromosomal Location of Human Ortholog: 17p13-p12

Cellular Component: endoplasmic reticulum membrane; membrane; cytoplasm; nuclear pore; cytosol; nucleus; annulate lamellae

Molecular Function:protein binding; RNA binding; ribosome binding; protein N-terminus binding; translation elongation factor activity; U6 snRNA binding

Biological Process: mRNA export from nucleus; translational frameshifting; cellular protein metabolic process; apoptosis; positive regulation of cell proliferation; nucleocytoplasmic transport; positive regulation of translational elongation; hypusine biosynthetic process from peptidyl-lysine; protein export from nucleus; post-translational protein modification; positive regulation of translational termination

UniProt Code:P63241
NCBI GenInfo Identifier:54037409
NCBI Gene ID:1984
NCBI Accession:P63241.2
UniProt Related Accession:P63241
Molecular Weight:~ 18kDa
NCBI Full Name:Eukaryotic translation initiation factor 5A-1
NCBI Synonym Full Names:eukaryotic translation initiation factor 5A
NCBI Official Symbol:EIF5A  
NCBI Official Synonym Symbols:EIF-5A; EIF5A1; eIF-4D; eIF5AI  
NCBI Protein Information:eukaryotic translation initiation factor 5A-1
UniProt Protein Name:Eukaryotic translation initiation factor 5A-1
UniProt Synonym Protein Names:Eukaryotic initiation factor 5A isoform 1; eIF-5A; Rev-binding factor; eIF-4D
Protein Family:Translation initiation factor
UniProt Gene Name:EIF5A  
UniProt Entry Name:IF5A1_HUMAN
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