KO Validated Antibodies 2
Anti-EIF4G2 Antibody (CAB19990)[KO Validated]
- SKU:
- CAB19990
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Antibody Name: | Anti-EIF4G2 Antibody [KO Validated] |
Antibody SKU: | CAB19990 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide of human EIF4G2. |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | 293T |
Immunogen: | A synthetic peptide of human EIF4G2. |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 1982 |
Uniprot: | P78344 |
Cellular Location: | |
Calculated MW: | 98kDa/102kDa |
Observed MW: | 97KDa |
Synonyms: | EIF4G2, AAG1, DAP5, NAT1, P97 |
Background: | Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. |
UniProt Protein Function: | EIF4G2: a general repressor of translation by forming translationally inactive complexes. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Interacts with the protein kinases Mnk1 and -2. Binds EIF4A and EIF3. Cleaved by some caspases and viral proteases. |
UniProt Protein Details: | Protein type:RNA-binding; Translation initiation; Translation Chromosomal Location of Human Ortholog: 11p15 Cellular Component: membrane; eukaryotic translation initiation factor 4F complex; cytosol Molecular Function:protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity Biological Process: cell death; cytokine and chemokine mediated signaling pathway; translational initiation; cell cycle arrest; regulation of translational initiation |
NCBI Summary: | Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | P78344 |
NCBI GenInfo Identifier: | 30315906 |
NCBI Gene ID: | 1982 |
NCBI Accession: | P78344.1 |
UniProt Secondary Accession: | P78344,O60877, P78404, Q0VH00, Q0VH01, Q2NKW9, Q49A79 Q53EU1, Q58EZ2, Q8NI71, Q96C16, |
UniProt Related Accession: | P78344 |
Molecular Weight: | 907 |
NCBI Full Name: | Eukaryotic translation initiation factor 4 gamma 2 |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 4 gamma, 2 |
NCBI Official Symbol: | EIF4G2 |
NCBI Official Synonym Symbols: | P97; AAG1; DAP5; NAT1 |
NCBI Protein Information: | eukaryotic translation initiation factor 4 gamma 2; DAP-5; EIF4G2; eIF4G 2; eIF-4G 2; eIF-4-gamma 2; aging-associated protein 1; death-associated protein 5; eukaryotic translation initiation factor 4G-like 1 |
UniProt Protein Name: | Eukaryotic translation initiation factor 4 gamma 2 |
UniProt Synonym Protein Names: | Death-associated protein 5; DAP-5; p97 |
Protein Family: | Eukaryotic translation initiation factor |
UniProt Gene Name: | EIF4G2 |
UniProt Entry Name: | IF4G2_HUMAN |