Metabolism Antibodies 1
Anti-EIF4G2 Antibody (CAB13616)
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- SKU:
- CAB13616
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-EIF4G2 Antibody |
| Antibody SKU: | CAB13616 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 750-850 of human EIF4G2 (NP_001409.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 750-850 of human EIF4G2 (NP_001409.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IYKW IKDN ISPK LHVD KGFV NILM TSFL QYIS SEVN PPSD ETDS SSAP SKEQ LEQE KQLL LSFK PVMQ KFLH DHVD LQVS ALYA LQVH CYNS NFPK GMLL R |
| Gene ID: | 1982 |
| Uniprot: | P78344 |
| Cellular Location: | |
| Calculated MW: | 98kDa/102kDa |
| Observed MW: | Refer to figures |
| Synonyms: | EIF4G2, AAG1, DAP5, NAT1, P97 |
| Background: | Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. |
| UniProt Protein Function: | EIF4G2: a general repressor of translation by forming translationally inactive complexes. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Interacts with the protein kinases Mnk1 and -2. Binds EIF4A and EIF3. Cleaved by some caspases and viral proteases. |
| UniProt Protein Details: | Protein type:RNA-binding; Translation initiation; Translation Chromosomal Location of Human Ortholog: 11p15 Cellular Component: membrane; eukaryotic translation initiation factor 4F complex; cytosol Molecular Function:protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity Biological Process: cell death; cytokine and chemokine mediated signaling pathway; translational initiation; cell cycle arrest; regulation of translational initiation |
| NCBI Summary: | Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78344 |
| NCBI GenInfo Identifier: | 30315906 |
| NCBI Gene ID: | 1982 |
| NCBI Accession: | P78344.1 |
| UniProt Secondary Accession: | P78344,O60877, P78404, Q0VH00, Q0VH01, Q2NKW9, Q49A79 Q53EU1, Q58EZ2, Q8NI71, Q96C16, |
| UniProt Related Accession: | P78344 |
| Molecular Weight: | 907 |
| NCBI Full Name: | Eukaryotic translation initiation factor 4 gamma 2 |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 4 gamma, 2 |
| NCBI Official Symbol: | EIF4G2 |
| NCBI Official Synonym Symbols: | P97; AAG1; DAP5; NAT1 |
| NCBI Protein Information: | eukaryotic translation initiation factor 4 gamma 2; DAP-5; EIF4G2; eIF4G 2; eIF-4G 2; eIF-4-gamma 2; aging-associated protein 1; death-associated protein 5; eukaryotic translation initiation factor 4G-like 1 |
| UniProt Protein Name: | Eukaryotic translation initiation factor 4 gamma 2 |
| UniProt Synonym Protein Names: | Death-associated protein 5; DAP-5; p97 |
| Protein Family: | Eukaryotic translation initiation factor |
| UniProt Gene Name: | EIF4G2 |
| UniProt Entry Name: | IF4G2_HUMAN |
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