Cell Biology Antibodies 14
Anti-EIF2B4 Antibody (CAB18203)
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- SKU:
- CAB18203
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-EIF2B4 Antibody |
| Antibody SKU: | CAB18203 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human EIF2B4 . |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat testis, Rat brain |
| Immunogen: | Recombinant protein of human EIF2B4 . |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8890 |
| Uniprot: | Q9UI10 |
| Cellular Location: | |
| Calculated MW: | 57kDa |
| Observed MW: | 57kDa |
 | Western blot - EIF2B4 Rabbit pAb (CAB18203) |
| Synonyms: | EIF2B, EIF-2B, EIF2Bdelta, EIF2B4 |
| Background: | Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | eIF2B-delta: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Defects in EIF2B4 are a cause of leukodystrophy with vanishing white matter (VWM). VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Belongs to the eIF-2B alpha/beta/delta subunits family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Translation initiation; Translation; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; S-methyl-5-thioribose-1-phosphate isomerase activity; translation initiation factor activity; translation initiation factor binding Biological Process: cellular protein metabolic process; cellular response to stimulus; gene expression; methionine salvage; myelination; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; oligodendrocyte development; ovarian follicle development; positive regulation of GTPase activity; regulation of translation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translation; translational initiation Disease: Leukoencephalopathy With Vanishing White Matter |
| NCBI Summary: | Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UI10 |
| NCBI GenInfo Identifier: | 28381357 |
| NCBI Gene ID: | 8890 |
| NCBI Accession: | Q9UI10.2 |
| UniProt Secondary Accession: | Q9UI10,Q53RY7, Q5BJF4, Q9BUV9, Q9UBG4, Q9UIQ9, Q9UJ95 |
| UniProt Related Accession: | Q9UI10 |
| Molecular Weight: | 57,458 Da |
| NCBI Full Name: | Translation initiation factor eIF-2B subunit delta |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 2B subunit delta |
| NCBI Official Symbol: | EIF2B4 |
| NCBI Official Synonym Symbols: | EIF2B; EIF-2B; EIF2Bdelta |
| NCBI Protein Information: | translation initiation factor eIF-2B subunit delta |
| UniProt Protein Name: | Translation initiation factor eIF-2B subunit delta |
| UniProt Synonym Protein Names: | eIF-2B GDP-GTP exchange factor subunit delta |
| Protein Family: | Translation initiation factor |
| UniProt Gene Name: | EIF2B4 |
| UniProt Entry Name: | EI2BD_HUMAN |
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