Anti-eIF2B epsilon (EIF2B5) Antibody (CAB8670)
- SKU:
- CAB8670
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CACH
- Synonyms:
- CLE
- Synonyms:
- EIF-2B
- Synonyms:
- EIF2Bepsilon
- Synonyms:
- LVWM
- Research Area:
- Metabolism
Description
| Product Name: | eIF2B epsilon (EIF2B5) Rabbit mAb |
| Product Code: | CAB8670 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human eIF2B epsilon (EIF2B5) (EIF2B5) |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HT-29, U-87MG |
| Immunogen: | A synthesized peptide derived from human eIF2B epsilon (EIF2B5) (EIF2B5) |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8893 |
| Uniprot: | Q13144 |
| Calculated MW: | 80kDa |
| Observed MW: | 80kDa |
| UniProt Protein Function: | eIF2B-epsilon: eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. |
| UniProt Protein Details: | Protein type:Translation; Translation initiation Chromosomal Location of Human Ortholog: 3q27.1 Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex; nucleus Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; translation initiation factor activity; translation initiation factor binding Biological Process: astrocyte development; astrocyte differentiation; myelination; negative regulation of translation initiation in response to stress; oligodendrocyte development; ovarian follicle development; positive regulation of translational initiation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation Disease: Leukoencephalopathy With Vanishing White Matter |
| NCBI Summary: | This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009] |
| UniProt Code: | Q13144 |
| NCBI GenInfo Identifier: | 160359049 |
| NCBI Gene ID: | 8893 |
| NCBI Accession: | Q13144.3 |
| UniProt Secondary Accession: | Q13144,Q541Z1, Q96D04, |
| UniProt Related Accession: | Q13144 |
| Molecular Weight: | 80kDa |
| NCBI Full Name: | Translation initiation factor eIF-2B subunit epsilon |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 2B subunit epsilon |
| NCBI Official Symbol: | EIF2B5 |
| NCBI Official Synonym Symbols: | CLE; CACH; LVWM; EIF-2B; EIF2Bepsilon |
| NCBI Protein Information: | translation initiation factor eIF-2B subunit epsilon |
| UniProt Protein Name: | Translation initiation factor eIF-2B subunit epsilon |
| UniProt Synonym Protein Names: | eIF-2B GDP-GTP exchange factor subunit epsilon |
| Protein Family: | Translation initiation factor |
| UniProt Gene Name: | EIF2B5 |
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