Cell Biology Antibodies 8
Anti-EGR1 Antibody (CAB2722)
- SKU:
- CAB2722
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-EGR1 Antibody |
| Antibody SKU: | CAB2722 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human EGR1 |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:1000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, A-549, OVCAR3, Mouse uterus, Rat uterus |
| Immunogen: | Recombinant protein of human EGR1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1958 |
| Uniprot: | P18146 |
| Cellular Location: | Nucleus |
| Calculated MW: | 57kDa |
| Observed MW: | 57kDa |
| Synonyms: | EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 |
| Background: | The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. |
| UniProt Protein Function: | EGR1: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family. |
| UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; metal ion binding; double-stranded DNA binding; transcription factor binding; transcription factor activity Biological Process: regulation of long-term neuronal synaptic plasticity; circadian rhythm; response to nutrient levels; transcription from RNA polymerase II promoter; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; response to amphetamine; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; BMP signaling pathway; response to ethanol; learning and/or memory; cellular response to insulin stimulus; positive regulation of neuron apoptosis; response to glucose stimulus; oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus; T cell differentiation; regulation of protein sumoylation; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P18146 |
| NCBI GenInfo Identifier: | 119242 |
| NCBI Gene ID: | 1958 |
| NCBI Accession: | P18146.1 |
| UniProt Related Accession: | P18146 |
| Molecular Weight: | 543 |
| NCBI Full Name: | Early growth response protein 1 |
| NCBI Synonym Full Names: | early growth response 1 |
| NCBI Official Symbol: | EGR1 |
| NCBI Official Synonym Symbols: | TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268 |
| NCBI Protein Information: | early growth response protein 1; EGR-1; zinc finger protein 225; transcription factor ETR103; transcription factor Zif268; zinc finger protein Krox-24; nerve growth factor-induced protein A |
| UniProt Protein Name: | Early growth response protein 1 |
| UniProt Synonym Protein Names: | AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24 |
| Protein Family: | Early growth response protein |
| UniProt Gene Name: | EGR1 |
| UniProt Entry Name: | EGR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EGR1 antibody (CAB2722) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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