Cell Biology Antibodies 14

Anti-DUSP8 Antibody (CAB17990)

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SKU:
CAB17990
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DUSP8 Antibody
Antibody SKU:CAB17990
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human DUSP8
Application:WB IF
Recommended Dilution:WB 1:200 - 1:1000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Raji, A-431
Immunogen:Recombinant protein of human DUSP8
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1850
Uniprot:Q13202
Cellular Location:Cytoplasm, Nucleus
Calculated MW:65kDa
Observed MW:66kDa
Anti-DUSP8 Antibody (CAB17990)Western blot - DUSP8 Polyclonal Antibody (CAB17990)
Synonyms:DUSP8, C11orf81, HB5, HVH-5, HVH8
Background:The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
UniProt Protein Function:DUSP8: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin.
UniProt Protein Details:

Protein type:Protein phosphatase, dual-specificity; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; nucleus

Molecular Function:protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: protein amino acid dephosphorylation; inactivation of MAPK activity

NCBI Summary:The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]
UniProt Code:Q13202
NCBI GenInfo Identifier:223590200
NCBI Gene ID:1850
NCBI Accession:Q13202.2
UniProt Related Accession:Q13202
Molecular Weight:
NCBI Full Name:Dual specificity protein phosphatase 8
NCBI Synonym Full Names:dual specificity phosphatase 8
NCBI Official Symbol:DUSP8  
NCBI Official Synonym Symbols:HB5; HVH8; HVH-5; C11orf81  
NCBI Protein Information:dual specificity protein phosphatase 8
UniProt Protein Name:Dual specificity protein phosphatase 8
UniProt Synonym Protein Names:Dual specificity protein phosphatase hVH-5
Protein Family:Dual specificity protein phosphatase
UniProt Gene Name:DUSP8  
UniProt Entry Name:DUS8_HUMAN
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