Cell Biology Antibodies 1
Anti-DUSP14 Antibody (CAB10287)
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- SKU:
- CAB10287
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DUSP14 Antibody |
| Antibody SKU: | CAB10287 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human DUSP14 (NP_008957.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:200 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Hela, SW480, BT-474, SKOV3, Mouse kidney, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human DUSP14 (NP_008957.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSR GHST LPRT LMAP RMIS EGDI GGIA QITS SLFL GRGS VASN RHLL QARG ITCI VNAT IEIP NFNW PQFE YVKV PLAD MPHA PIGL YFDT VADK IHSV SRKH GATL VHCA AGVS RSAT LCIA YLMK FHNV CLLE AYNW VKAR RPVI RPNV GFWR QLID YERQ LFGK STVK MVQT PYGI VPDV YEKE SRHL MPYW GI |
| Gene ID: | 11072 |
| Uniprot: | O95147 |
| Cellular Location: | |
| Calculated MW: | 22kDa |
| Observed MW: | 22kDa |
| Synonyms: | DUSP14, MKP-L, MKP6 |
| Background: |
| UniProt Protein Function: | DUSP14: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Is a negative regulator of T cell costimulation via CD28. |
| UniProt Protein Details: | Protein type:EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 17q12 Molecular Function:protein binding; RNA binding |
| NCBI Summary: | Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] |
| UniProt Code: | O95147 |
| NCBI GenInfo Identifier: | 20137720 |
| NCBI Gene ID: | 11072 |
| NCBI Accession: | O95147.1 |
| UniProt Related Accession: | O95147 |
| Molecular Weight: | 22kDa |
| NCBI Full Name: | Dual specificity protein phosphatase 14 |
| NCBI Synonym Full Names: | dual specificity phosphatase 14 |
| NCBI Official Symbol: | DUSP14 |
| NCBI Official Synonym Symbols: | MKP6; MKP-L |
| NCBI Protein Information: | dual specificity protein phosphatase 14 |
| UniProt Protein Name: | Dual specificity protein phosphatase 14 |
| UniProt Synonym Protein Names: | MKP-1-like protein tyrosine phosphatase; MKP-L; Mitogen-activated protein kinase phosphatase 6; MAP kinase phosphatase 6; MKP-6 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP14 |
 | Western blot analysis of extracts of various cell lines, using DUSP14 antibody (CAB10287) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
 | Immunofluorescence analysis of H9C2 cells using DUSP14 Rabbit pAb (CAB10287) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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