Developmental Biology
Anti-DNMT3L Antibody (CAB2342)
- SKU:
- CAB2342
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-DNMT3L Antibody |
| Antibody SKU: | CAB2342 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-386 of human DNMT3L (NP_787063.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:50 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-386 of human DNMT3L (NP_787063.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAI PALD PEAE PSMD VILV GSSE LSSS VSPG TGRD LIAY EVKA NQRN IEDI CICC GSLQ VHTQ HPLF EGGI CAPC KDKF LDAL FLYD DDGY QSYC SICC SGET LLIC GNPD CTRC YCFE CVDS LVGP GTSG KVHA MSNW VCYL CLPS SRSG LLQR RRKW RSQL KAFY DRES ENPL EMFE TVPV WRRQ PVRV LSLF EDIK KELT SLGF LESG SDPG QLKH VVDV TDTV RKDV EEWG PFDL VYGA TPPL GHTC DRPP SWYL FQFH RLLQ YARP KPGS PRPF FWMF VDNL VLNK EDLD VASR FLEM EPVT IPDV HGGS LQNA VRVW SNIP AIRS RHWA LVSE EELS LLAQ NKQS SKLA AKWP TKLV KNCF LPLR EYFK YFST ELTS SL |
| Gene ID: | 29947 |
| Uniprot: | Q9UJW3 |
| Cellular Location: | Nucleus |
| Calculated MW: | 43kDa |
| Observed MW: |
| Synonyms: | DNMT3L |
| Background: | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Code: | Q9UJW3 |
| NCBI GenInfo Identifier: | 334302913 |
| NCBI Gene ID: | 29947 |
| NCBI Accession: | Q9UJW3.3 |
| Molecular Weight: | 45kDa |
| NCBI Full Name: | DNA (cytosine-5)-methyltransferase 3-like |
| UniProt Protein Name: | DNA (cytosine-5)-methyltransferase 3-like |
| Protein Family: | DNA (cytosine-5)-methyltransferase |
| UniProt Gene Name: | DNMT3L |
| UniProt Entry Name: | DNM3L_HUMAN |
 | Immunohistochemistry of paraffin-embedded rat testis using DNMT3L antibody (CAB2342) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using DNMT3L antibody (CAB2342) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using DNMT3L antibody (CAB2342) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using DNMT3L antibody (CAB2342). |
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