Epigenetics & Nuclear Signaling Antibodies 3
Anti-DNAJC2 Antibody (CAB4633)
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- SKU:
- CAB4633
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DNAJC2
- Synonyms:
- MPHOSPH11
- Synonyms:
- MPP11
- Synonyms:
- ZRF1
- Synonyms:
- ZUO1
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | DNAJC2 Rabbit pAb |
| Product Code: | CAB4633 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | DNAJC2, MPHOSPH11, MPP11, ZRF1, ZUO1 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human DNAJC2 (NP_055192.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, MCF7, HeLa, A-549, Mouse testis, Mouse spleen, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human DNAJC2 (NP_055192.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLLL PSAA DGRG TAIT HALT SAST LCQV EPVG RWFE AFVK RRNR NASA SFQE LEDK KELS EESE DEEL QLEE FPML KTLD PKDW KNQD HYAV LGLG HVRY KATQ RQIK AAHK AMVL KHHP DKRK AAGE PIKE GDND YFTC |
| Gene ID: | 27000 |
| Uniprot: | Q99543 |
| Cellular Location: | Cytoplasm, Nucleus, cytosol |
| Calculated MW: | 65kDa/71kDa |
| Observed MW: | 72kDa |
| UniProt Protein Function: | DNAJC2: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA replication; Chaperone; Cell cycle regulation Chromosomal Location of Human Ortholog: 7q22 Cellular Component: nuclear membrane; cytoplasm; cytosol; nucleus Molecular Function:ubiquitin binding; DNA binding; histone binding; Hsp70 protein binding; chromatin binding Biological Process: 'de novo' cotranslational protein folding; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of cell growth; chromatin modification; DNA replication |
| NCBI Summary: | This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99543 |
| NCBI GenInfo Identifier: | 296439472 |
| NCBI Gene ID: | 27000 |
| NCBI Accession: | Q99543.4 |
| UniProt Related Accession: | Q99543 |
| Molecular Weight: | |
| NCBI Full Name: | DnaJ homolog subfamily C member 2 |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member C2 |
| NCBI Official Symbol: | DNAJC2 |
| NCBI Official Synonym Symbols: | ZRF1; ZUO1; MPP11; MPHOSPH11 |
| NCBI Protein Information: | dnaJ homolog subfamily C member 2 |
| UniProt Protein Name: | DnaJ homolog subfamily C member 2 |
| UniProt Synonym Protein Names: | M-phase phosphoprotein 11; Zuotin-related factor 1DnaJ homolog subfamily C member 2, N-terminally processed |
| UniProt Gene Name: | DNAJC2 |
| UniProt Entry Name: | DNJC2_HUMAN |
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OverviewProduct Name:DNAJC2 Polyclonal AntibodyProduct Code:CAB21431Reactivity:Human, MouseApplications:Western blotting
