Epigenetics & Nuclear Signaling Antibodies 5
Anti-DNA Polymerase beta Antibody (CAB2412)
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- SKU:
- CAB2412
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-DNA Polymerase beta Antibody |
| Antibody SKU: | CAB2412 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human DNA Polymerase beta |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, A-431, Jurkat, Mouse testis, Mouse spleen, Mouse thymus, Rat testis, Rat spleen |
| Immunogen: | A synthesized peptide derived from human DNA Polymerase beta |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5423 |
| Uniprot: | P06746 |
| Cellular Location: | |
| Calculated MW: | 38kDa |
| Observed MW: | 42KDa |
| Synonyms: | |
| Background: | The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011] |
| UniProt Protein Function: | POLB: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Monomer. Interacts with APEX1, HUWE1/ARF-BP1, STUB1/CHIP and USP47. Belongs to the DNA polymerase type-X family. |
| UniProt Protein Details: | Protein type:EC 2.7.7.7; Transferase; Lyase; DNA replication; DNA repair, damage Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: nucleoplasm; microtubule; spindle microtubule; cytoplasm; nucleus Molecular Function:protein binding; enzyme binding; metal ion binding; microtubule binding; damaged DNA binding; DNA-directed DNA polymerase activity; lyase activity Biological Process: base-excision repair, gap-filling; neuron apoptosis; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; base-excision repair; pyrimidine dimer repair; nucleotide-excision repair, DNA gap filling; DNA repair; DNA-dependent DNA replication; response to DNA damage stimulus |
| NCBI Summary: | The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011] |
| UniProt Code: | P06746 |
| NCBI GenInfo Identifier: | 4505931 |
| NCBI Gene ID: | 5423 |
| NCBI Accession: | NP_002681.1 |
| UniProt Related Accession: | P06746 |
| Molecular Weight: | ~ 38kDa |
| NCBI Full Name: | DNA polymerase beta |
| NCBI Synonym Full Names: | DNA polymerase beta |
| NCBI Official Symbol: | POLB |
| NCBI Protein Information: | DNA polymerase beta |
| UniProt Protein Name: | DNA polymerase beta |
| UniProt Gene Name: | POLB |
| UniProt Entry Name: | DPOLB_HUMAN |
 | Western blot - DNA Polymerase beta Rabbit mAb (CAB2412) |
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