Anti-DLX5 Antibody (CAB5586)

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SKU:
CAB5586
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SHFM1D
Research Area:
Cell Biology

Description

Product Name:DLX5 Rabbit mAb
Product Code:CAB5586
Size:20uL, 50uL, 100uL
Synonyms:SHFM1D
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human DLX5
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, 293T, U-87MG
Immunogen:A synthesized peptide derived from human DLX5
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1749
Uniprot:P56178
Cellular Location:Nucleus
Calculated MW:32kDa
Observed MW:32kDa
UniProt Protein Function:DLX5: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. Defects in DLX5 are the cause of split-hand/foot malformation type 1, with sensorineural hearing loss (SHFM1D). A disease characterized by the association of split- hand/foot malformation with deafness. Split-hand/foot malformation is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. Belongs to the distal-less homeobox family.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: nuclear chromatin

Biological Process: BMP signaling pathway; cell proliferation; endochondral ossification; nervous system development; osteoblast differentiation; positive regulation of transcription, DNA-dependent; skeletal development

Disease: Split-hand/foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive

NCBI Summary:This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008]
UniProt Code:P56178
NCBI GenInfo Identifier:12644329
NCBI Gene ID:1749
NCBI Accession:P56178.2
UniProt Secondary Accession:P56178,Q9UPL1, B7Z4P3,
UniProt Related Accession:P56178
Molecular Weight:20,900 Da
NCBI Full Name:Homeobox protein DLX-5
NCBI Synonym Full Names:distal-less homeobox 5
NCBI Official Symbol:DLX5  
NCBI Official Synonym Symbols:SHFM1D  
NCBI Protein Information:homeobox protein DLX-5
UniProt Protein Name:Homeobox protein DLX-5
Protein Family:Homeobox protein
UniProt Gene Name:DLX5  
UniProt Entry Name:DLX5_HUMAN
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