Anti-Desmocollin 3 Antibody (CAB0445)
- SKU:
- CAB0445
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| Product Name: | Desmocollin 3 Rabbit mAb |
| Product Code: | CAB0445 |
| Size: | 20uL, 50uL, 100uL |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Desmocollin 3. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | TE-1 |
| Immunogen: | A synthesized peptide derived from human Desmocollin 3. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1825 |
| Uniprot: | Q14574 |
| Calculated MW: | 100kDa |
| Observed MW: | 100KDa |
| UniProt Protein Function: | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q14574 |
| NCBI GenInfo Identifier: | 116241342 |
| NCBI Gene ID: | 1825 |
| NCBI Accession: | Q14574.3 |
| UniProt Secondary Accession: | Q14574,Q14200, Q9HAZ9, A6NN35 |
| UniProt Related Accession: | Q14574 |
| Molecular Weight: | 93,454 Da |
| NCBI Full Name: | Desmocollin-3 |
| NCBI Synonym Full Names: | desmocollin 3 |
| NCBI Official Symbol: | DSC3 |
| NCBI Official Synonym Symbols: | DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP |
| NCBI Protein Information: | desmocollin-3 |
| UniProt Protein Name: | Desmocollin-3 |
| UniProt Synonym Protein Names: | Cadherin family member 3; Desmocollin-4; HT-CP |
| Protein Family: | Desmocollin |
| UniProt Gene Name: | DSC3 |
| UniProt Entry Name: | DSC3_HUMAN |
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