Anti-DCR2 Antibody (CAB3581)

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SKU:
CAB3581
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CD264
Synonyms:
DCR2
Synonyms:
TRAIL-R4
Synonyms:
TRAILR4
Synonyms:
TRUNDD
Research Area:
Cell Death

Description

Product Name:DCR2 Rabbit mAb
Product Code:CAB3581
Size:20uL, 50uL, 100uL
Synonyms:CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human DCR2
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver, Mouse kidney, Rat liver, Rat kidney
Immunogen:A synthesized peptide derived from human DCR2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8793
Uniprot:Q9UBN6
Calculated MW:36kDa
Observed MW:45-60KDa
UniProt Protein Function:TRAIL-R4: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: integral to membrane

Molecular Function:transmembrane receptor activity; TRAIL binding

Biological Process: apoptosis; signal transduction; negative regulation of apoptosis

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UBN6
NCBI GenInfo Identifier:18203495
NCBI Gene ID:8793
NCBI Accession:Q9UBN6.1
UniProt Secondary Accession:Q9UBN6,Q9Y6Q4, B2R8W0,
UniProt Related Accession:Q9UBN6
Molecular Weight:41,823 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 10D
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
NCBI Official Symbol:TNFRSF10D  
NCBI Official Synonym Symbols:DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 10D; TRAIL receptor 4; decoy receptor 2; TNF receptor-related receptor for TRAIL; TRAIL receptor with a truncated death domain; TNF-related apoptosis-inducing ligand receptor 4
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 10D
UniProt Synonym Protein Names:Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD_antigen: CD264
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:TNFRSF10D  
UniProt Entry Name:TR10D_HUMAN
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