Epigenetics & Nuclear Signaling Antibodies 1
Anti-DCPS Antibody (CAB10299)
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- SKU:
- CAB10299
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-DCPS Antibody |
| Antibody SKU: | CAB10299 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DCPS (NP_054745.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DCPS (NP_054745.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MADA APQL GKRK RELD VEEA HAAS TEEK EAGV GNGT CAPV RLPF SGFR LQKV LRES ARDK IIFL HGKV NEAS GDGD GEDA VVIL EKTP FQVE QVAQ LLTG SPEL QLQF SNDI YSTY HLFP PRQL NDVK TTVV YPAT EKHL QKYL RQDL RLIR ETGD DYRN ITLP HLES QSLS IQWV YNIL DKKA EADR IVFE NPDP SDGF VLIP DLKW NQQQ LDDL YLIA ICHR RGIR SLRD LTPE HLPL LRNI LHQG QEAI LQRY RMKG DHLR VYLH YL |
| Gene ID: | 28960 |
| Uniprot: | Q96C86 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 38kDa |
| Observed MW: | 38kDa |
| Synonyms: | DCPS, ARS, DCS1, HINT-5, HINT5, HSL1, HSPC015 |
| Background: |
| UniProt Protein Function: | DCPS: Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides. Belongs to the HIT family. |
| UniProt Protein Details: | Protein type:EC 3.6.1.59; Hydrolase; RNA splicing Chromosomal Location of Human Ortholog: 11q24.2 Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus Molecular Function:exoribonuclease activity; m7G(5')pppN diphosphatase activity; protein binding; RNA 7-methylguanosine cap binding Biological Process: deadenylation-dependent decapping; mRNA catabolic process, deadenylation-dependent decay; negative regulation of programmed cell death; nuclear mRNA cis splicing, via U2-type spliceosome Disease: Al-raqad Syndrome |
| NCBI Summary: | This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017] |
| UniProt Code: | Q96C86 |
| NCBI GenInfo Identifier: | 116241325 |
| NCBI Gene ID: | 28960 |
| NCBI Accession: | Q96C86.2 |
| UniProt Secondary Accession: | Q96C86,Q8NHL8, Q9Y2S5, |
| UniProt Related Accession: | Q96C86 |
| Molecular Weight: | 39kDa |
| NCBI Full Name: | m7GpppX diphosphatase |
| NCBI Synonym Full Names: | decapping enzyme, scavenger |
| NCBI Official Symbol: | DCPS |
| NCBI Official Synonym Symbols: | ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015 |
| NCBI Protein Information: | m7GpppX diphosphatase |
| UniProt Protein Name: | m7GpppX diphosphatase |
| UniProt Synonym Protein Names: | DCS-1; Decapping scavenger enzyme; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; HINT-5; Scavenger mRNA-decapping enzyme DcpS |
| Protein Family: | m7GpppX diphosphatase |
| UniProt Gene Name: | DCPS |
 | Western blot analysis of extracts of HT-29 cells, using DCPS antibody (CAB10299) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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