Cell Biology Antibodies 11
Anti-DCD Antibody (CAB7280)
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- SKU:
- CAB7280
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DCD Antibody |
| Antibody SKU: | CAB7280 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human DCD (NP_444513.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse skin |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human DCD (NP_444513.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YDPE AASA PGSG NPCH EASA AQKE NAGE DPGL ARQA PKPR KQRS SLLE KGLD GAKK AVGG LGKL GKDA VEDL ESVG KGAV HDVK DVLD SVL |
| Gene ID: | 117159 |
| Uniprot: | P81605 |
| Cellular Location: | Secreted |
| Calculated MW: | 8kDa/11kDa/12kDa |
| Observed MW: | 11kDa |
| Synonyms: | DCD, AIDD, DCD-1, DSEP, HCAP, PIF, dermcidin |
| Background: | This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | DCD: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.4.-.-; Secreted Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: extracellular region Molecular Function:protein binding |
| NCBI Summary: | This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P81605 |
| NCBI GenInfo Identifier: | 20141302 |
| NCBI Gene ID: | 117159 |
| NCBI Accession: | P81605.2 |
| UniProt Secondary Accession: | P81605,P58461, Q53YJ2, A5JHP2, A5JHP3, |
| UniProt Related Accession: | P81605 |
| Molecular Weight: | 8,295 Da |
| NCBI Full Name: | Dermcidin |
| NCBI Synonym Full Names: | dermcidin |
| NCBI Official Symbol: | DCD |
| NCBI Official Synonym Symbols: | PIF; AIDD; DSEP; HCAP; DCD-1 |
| NCBI Protein Information: | dermcidin |
| UniProt Protein Name: | Dermcidin |
| UniProt Synonym Protein Names: | Preproteolysin |
| Protein Family: | Dermcidin |
| UniProt Gene Name: | DCD |
| UniProt Entry Name: | DCD_HUMAN |
 | Western blot analysis of extracts of mouse skin, using DCD antibody (CAB7280) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 5s. |
 | Immunofluorescence analysis of MCF-7 cells using DCD antibody (CAB7280). Blue: DAPI for nuclear staining. |
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