Immunology Antibodies 1
Anti-DBNL Antibody (CAB13751)
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- SKU:
- CAB13751
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-DBNL Antibody |
| Antibody SKU: | CAB13751 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 131-430 of human DBNL (NP_001014436.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, MCF-7, Jurkat, K-562, Mouse brain, Mouse thymus, Mouse spleen, Mouse testis, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 131-430 of human DBNL (NP_001014436.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KVAK ASGA NYSF HKES GRFQ DVGP QAPV GSVY QKTN AVSE IKRV GKDS FWAK AEKE EENR RLEE KRRA EEAQ RQLE QERR EREL REAA RREQ RYQE QGGE ASPQ RTWE QQQE VVSR NRNE QESA VHPR EIFK QKER AMST TSIS SPQP GKLR SPFL QKQL TQPE THFG REPA AAIS RPRA DLPA EEPA PSTP PCLV QAEE EAVY EEPP EQET FYEQ PPLV QQQG AGSE HIDH HIQG QGLS GQGL CARA LYDY QAAD DTEI SFDP ENLI TGIE VIDE GWWR GYGP DGHF GMFP ANYV ELIE |
| Gene ID: | 28988 |
| Uniprot: | Q9UJU6 |
| Cellular Location: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Peripheral membrane protein, cell cortex, clathrin-coated vesicle membrane, cytoskeleton, cytosol, lamellipodium, podosome, ruffle, synapse |
| Calculated MW: | 37kDa/43kDa/48kDa/49kDa |
| Observed MW: | 56kDa |
| Synonyms: | DBNL, ABP1, HIP-55, HIP55, SH3P7 |
| Background: |
| UniProt Protein Function: | DBNL: an SH3-containing adaptor protein. Interacts with hematopoietic progenitor kinase 1a (HIPK1). It is recruited to glycolipid-enriched microdomains following T cell receptor (TCR) stimulation. Interacts with and is phosphorylated by ZAP-70 after TCR signaling. May regulate JNK activation following TCR signaling, presumably via its interaction with HIPKIt is a member of the drebrin family of proteins that are developmentally regulated in the brain. |
| UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7p13 Cellular Component: Golgi membrane; ruffle; lamellipodium; dendrite; postsynaptic density; cytoplasm; plasma membrane; clathrin coated vesicle membrane; podosome; cell cortex; cytosol; cell junction Molecular Function:actin filament binding; protein C-terminus binding; protein domain specific binding; protein binding; enzyme activator activity; actin binding Biological Process: receptor-mediated endocytosis; synaptogenesis; immune system process; apoptosis; Rac protein signal transduction; neurite morphogenesis; activation of JNK activity; cell structure disassembly during apoptosis |
| UniProt Code: | Q9UJU6 |
| NCBI GenInfo Identifier: | 51316115 |
| NCBI Gene ID: | 28988 |
| NCBI Accession: | Q9UJU6.1 |
| UniProt Related Accession: | Q9UJU6 |
| Molecular Weight: | 48207 |
| NCBI Full Name: | Drebrin-like protein |
| NCBI Synonym Full Names: | drebrin like |
| NCBI Official Symbol: | DBNL |
| NCBI Official Synonym Symbols: | ABP1; HIP55; SH3P7; HIP-55 |
| NCBI Protein Information: | drebrin-like protein |
| UniProt Protein Name: | Drebrin-like protein |
| UniProt Synonym Protein Names: | Cervical SH3P7; Cervical mucin-associated protein; Drebrin-F; HPK1-interacting protein of 55 kDa; HIP-55; SH3 domain-containing protein 7 |
| Protein Family: | Drebrin-like protein |
| UniProt Gene Name: | DBNL |
| UniProt Entry Name: | DBNL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DBNL antibody (CAB13751) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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