Anti-Cytokeratin 4 (KRT4) Antibody (CAB0013)
- SKU:
- CAB0013
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CK-4
- Synonyms:
- CK4
- Synonyms:
- CYK4
- Synonyms:
- K4
- Synonyms:
- WSN1
- Research Area:
- Cell Biology
Description
| Product Name: | Cytokeratin 4 (KRT4) Rabbit mAb |
| Product Code: | CAB0013 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CK-4, CK4, CYK4, K4, WSN1 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Cytokeratin 4 (KRT4) (KRT4) |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, A-431, Mouse stomach |
| Immunogen: | A synthesized peptide derived from human Cytokeratin 4 (KRT4) (KRT4) |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3851 |
| Uniprot: | P19013 |
| Calculated MW: | 57kDa |
| Observed MW: | 57kDa |
| UniProt Protein Function: | K4: Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13. Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa. Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer. Belongs to the intermediate filament family. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: intermediate filament cytoskeleton; cell surface; keratin filament; intermediate filament; nucleus Molecular Function:protein binding; structural molecule activity Biological Process: epithelial cell differentiation; cytoskeleton organization and biogenesis; negative regulation of epithelial cell proliferation Disease: White Sponge Nevus 1 |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P19013 |
| NCBI GenInfo Identifier: | 82654947 |
| NCBI Gene ID: | 3851 |
| NCBI Accession: | P19013.4 |
| UniProt Related Accession: | P19013 |
| Molecular Weight: | |
| NCBI Full Name: | Keratin, type II cytoskeletal 4 |
| NCBI Synonym Full Names: | keratin 4 |
| NCBI Official Symbol: | KRT4 |
| NCBI Official Synonym Symbols: | K4; CK4; CK-4; CYK4; WSN1 |
| NCBI Protein Information: | keratin, type II cytoskeletal 4 |
| UniProt Protein Name: | Keratin, type II cytoskeletal 4 |
| UniProt Synonym Protein Names: | Cytokeratin-4; CK-4; Keratin-4; K4; Type-II keratin Kb4 |
| UniProt Gene Name: | KRT4 |
| UniProt Entry Name: | K2C4_HUMAN |
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