Anti-Cytokeratin 18 (KRT18) Antibody (CAB19778)

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SKU:
CAB19778
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CK18
Synonyms:
K18
Synonyms:
Krt1-18
Research Area:
Cell Cycle

Description

Product Name:Cytokeratin 18 (KRT18) Rabbit mAb
Product Code:CAB19778
Size:20uL, 50uL, 100uL
Synonyms:CK18, K18, Krt1-18
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Cytokeratin 18 (KRT18)
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:1000 - 1:3000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, A-431
Immunogen:A synthesized peptide derived from human Cytokeratin 18 (KRT18)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3875
Uniprot:P05783
Calculated MW:43, 48kDa
Observed MW:48KDa
UniProt Protein Function:K18: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis.
UniProt Protein Details:

Protein type:Nucleolus; Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cytoplasm; intermediate filament; keratin filament; microtubule organizing center; nucleolus; perinuclear region of cytoplasm

Molecular Function:protein binding; structural molecule activity

Biological Process: anatomical structure morphogenesis; cell cycle; Golgi to plasma membrane CFTR protein transport; intermediate filament cytoskeleton organization and biogenesis; negative regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; viral reproduction

Disease: Cirrhosis, Familial

NCBI Summary:KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P05783
NCBI GenInfo Identifier:125083
NCBI Gene ID:3875
NCBI Accession:P05783.2
UniProt Secondary Accession:P05783,Q53G38, Q5U0N8, Q9BW26,
UniProt Related Accession:P05783
Molecular Weight:
NCBI Full Name:Keratin, type I cytoskeletal 18
NCBI Synonym Full Names:keratin 18
NCBI Official Symbol:KRT18  
NCBI Official Synonym Symbols:K18; CK-18; CYK18  
NCBI Protein Information:keratin, type I cytoskeletal 18
UniProt Protein Name:Keratin, type I cytoskeletal 18
UniProt Synonym Protein Names:Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18
Protein Family:Keratin
UniProt Gene Name:KRT18  
UniProt Entry Name:K1C18_HUMAN
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