Cell Biology Antibodies 17

Anti-Cytokeratin 14 Antibody (CAB19039)

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SKU:
CAB19039
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Cytokeratin 14 Antibody
Antibody SKU:CAB19039
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Cytokeratin 14
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SKOV3
Immunogen:A synthesized peptide derived from human Cytokeratin 14
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3861
Uniprot:P02533
Cellular Location:Cytoplasm, Nucleus
Calculated MW:53kDa
Observed MW:53kDa
Anti-Cytokeratin 14 Antibody (CAB19039)Western blot - Cytokeratin 14 Rabbit mAb (CAB19039)
Synonyms:CK14, EBS3, EBS4, K14, NFJ, Cytokeratin 14, KRT14
Background:This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
UniProt Protein Function:K14: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K5.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; keratin filament; intermediate filament; cytosol; nucleus

Molecular Function:protein binding; structural constituent of cytoskeleton

Biological Process: epidermis development; hemidesmosome assembly; epithelial cell differentiation; response to zinc ion; response to ionizing radiation; intermediate filament bundle assembly; hair cycle; aging

Disease: Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Simplex, Generalized; Dermatopathia Pigmentosa Reticularis; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Naegeli Syndrome; Epidermolysis Bullosa Simplex, Dowling-meara Type

NCBI Summary:This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
UniProt Code:P02533
NCBI GenInfo Identifier:229463044
NCBI Gene ID:3861
NCBI Accession:P02533.4
UniProt Secondary Accession:P02533,P08779,
UniProt Related Accession:P02533
Molecular Weight:~ 52kDa
NCBI Full Name:Keratin, type I cytoskeletal 14
NCBI Synonym Full Names:keratin 14
NCBI Official Symbol:KRT14  
NCBI Official Synonym Symbols:K14; NFJ; CK14; EBS3; EBS4  
NCBI Protein Information:keratin, type I cytoskeletal 14
UniProt Protein Name:Keratin, type I cytoskeletal 14
UniProt Synonym Protein Names:Cytokeratin-14; CK-14; Keratin-14; K14
Protein Family:Putative outer capsid protein
UniProt Gene Name:KRT14  
UniProt Entry Name:K1C14_HUMAN
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