Cell Biology Antibodies 2
Anti-CYBA Antibody (CAB10694)
- SKU:
- CAB10694
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CYBA Antibody |
| Antibody SKU: | CAB10694 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 126-195 of human CYBA (NP_000092.2). |
| Application: | IHC IF |
| Recommended Dilution: | IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 126-195 of human CYBA (NP_000092.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VRGE QWTP IEPK PRER PQIG GTIK QPPS NPPP RPPA EARK KPSE EEAA VAAG GPPG GPQV NPIP VTDE VV |
| Gene ID: | 1535 |
| Uniprot: | P13498 |
| Cellular Location: | Cell membrane |
| Calculated MW: | 21kDa |
| Observed MW: |
| Synonyms: | CYBA, p22-PHOX |
| Background: | Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. |
| UniProt Protein Function: | CYBA: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. Belongs to the p22phox family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.-.-.-; Membrane protein, integral Chromosomal Location of Human Ortholog: 16q24 Cellular Component: endoplasmic reticulum membrane; membrane; NADPH oxidase complex; phagocytic vesicle membrane; plasma membrane; secretory granule Molecular Function:electron carrier activity; protein binding; protein heterodimerization activity; SH3 domain binding; superoxide-generating NADPH oxidase activity Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; cytochrome complex assembly; hydrogen peroxide biosynthetic process; inflammatory response; innate immune response; positive regulation of interleukin-6 production; positive regulation of phagocytosis; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of tumor necrosis factor production; respiratory burst; response to reactive oxygen species; smooth muscle hypertrophy; superoxide metabolic process; superoxide release; vascular endothelial growth factor receptor signaling pathway Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-negative |
| NCBI Summary: | Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13498 |
| NCBI GenInfo Identifier: | 311033459 |
| NCBI Gene ID: | 1535 |
| NCBI Accession: | P13498.3 |
| UniProt Secondary Accession: | P13498,Q14090, Q9BR72, |
| UniProt Related Accession: | P13498 |
| Molecular Weight: | 21,013 Da |
| NCBI Full Name: | Cytochrome b-245 light chain |
| NCBI Synonym Full Names: | cytochrome b-245 alpha chain |
| NCBI Official Symbol: | CYBA |
| NCBI Official Synonym Symbols: | p22-PHOX |
| NCBI Protein Information: | cytochrome b-245 light chain |
| UniProt Protein Name: | Cytochrome b-245 light chain |
| UniProt Synonym Protein Names: | Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYBA |
| UniProt Entry Name: | CY24A_HUMAN |
 | Immunohistochemistry of paraffin-embedded human tonsil using CYBA antibody (CAB10694) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using CYBA antibody (CAB10694) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using CYBA antibody (CAB10694) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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