Cell Biology Antibodies 15

Anti-CXXC4 Antibody (CAB7837)

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SKU:
CAB7837
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CXXC4 Antibody
Antibody SKU:CAB7837
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CXXC4 (NP_079488.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CXXC4 (NP_079488.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNTN VCVE PGPS PEAP GLPK ESHL PEGA LNSL VDYN SEME RYRS FATS FYKT NGGA FPQA AKIA RITT PIFP SSAA AAAA AARI GMSP WNCD NAAT AAAA TAML WGSG GGGG GGGG GGGG GGGG GGGG GGGG GGRK SSSA AASS SASS SSAI LPAG GGGG GGGG GSRT SMHH RNDS QRLG KAGC PPEP SLQM ANTN FL
Gene ID:80319
Uniprot:Q9H2H0
Cellular Location:Cytoplasm
Calculated MW:20kDa
Observed MW:Refer to figures
Synonyms:CXXC4, IDAX
Background:This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CXXC4: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.
UniProt Protein Details:

Protein type:Inhibitor

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle

Molecular Function:DNA binding; zinc ion binding; PDZ domain binding

Biological Process: zygotic determination of dorsal/ventral axis; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway

UniProt Code:Q9H2H0
NCBI GenInfo Identifier:74752605
NCBI Gene ID:80319
NCBI Accession:Q9H2H0.1
UniProt Related Accession:Q9H2H0
Molecular Weight:20,978 Da
NCBI Full Name:CXXC-type zinc finger protein 4
NCBI Synonym Full Names:CXXC finger protein 4
NCBI Official Symbol:CXXC4  
NCBI Official Synonym Symbols:IDAX  
NCBI Protein Information:CXXC-type zinc finger protein 4; CXXC finger 4; inhibition of the Dvl and axin complex protein; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)
UniProt Protein Name:CXXC-type zinc finger protein 4
UniProt Synonym Protein Names:Inhibition of the Dvl and axin complex protein
Protein Family:CXXC-type zinc finger protein
UniProt Gene Name:CXXC4  
UniProt Entry Name:CXXC4_HUMAN
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