Immunology Antibodies 3
Anti-Cullin 2 Antibody (CAB5076)
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- SKU:
- CAB5076
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CUL2
- Synonyms:
- cullin-2
- Research Area:
- Immunology
Description
| Product Name: | Cullin 2 Rabbit mAb |
| Product Code: | CAB5076 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CUL2, cullin-2 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Cullin 2 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse liver, Rat testis, Rat brain |
| Immunogen: | A synthesized peptide derived from human Cullin 2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8453 |
| Uniprot: | Q13617 |
| Calculated MW: | 87kDa |
| Observed MW: | 87KDa |
| UniProt Protein Function: | CUL2: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). Belongs to the cullin family. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Cell cycle regulation Chromosomal Location of Human Ortholog: 10p11.21 Cellular Component: Cul2-RING ubiquitin ligase complex; nucleoplasm; cytosol Molecular Function:protein binding; ubiquitin protein ligase binding Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; viral reproduction; protein ubiquitination; cell cycle arrest; G1/S transition of mitotic cell cycle |
| UniProt Code: | Q13617 |
| NCBI GenInfo Identifier: | 19863260 |
| NCBI Gene ID: | 8453 |
| NCBI Accession: | Q13617.2 |
| UniProt Secondary Accession: | Q13617,O00200, Q5T2B6, Q9UNF9, B3KT95, B7Z6K8, D3DRY6 G3V1S2, |
| UniProt Related Accession: | Q13617 |
| Molecular Weight: | 745 |
| NCBI Full Name: | Cullin-2 |
| NCBI Synonym Full Names: | cullin 2 |
| NCBI Official Symbol: | CUL2 |
| NCBI Protein Information: | cullin-2; CUL-2 |
| UniProt Protein Name: | Cullin-2 |
| Protein Family: | Cullin |
| UniProt Gene Name: | CUL2 |
| UniProt Entry Name: | CUL2_HUMAN |
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