Cell Biology Antibodies 3

Anti-CTNND2 Antibody (CAB12633)

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SKU:
CAB12633
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CTNND2 Antibody
Antibody SKU:CAB12633
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 966-1225 of human CTNND2 (NP_001323.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:3000
Reactivity:Human, Rat
Positive Samples:PC-12
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 966-1225 of human CTNND2 (NP_001323.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TLHE VITK NMEN AKAL RDAG GIEK LVGI SKSK GDKH SPKV VKAA SQVL NSMW QYRD LRSL YKKD GWSQ YHFV ASSS TIER DRQR PYSS SRTP SISP VRVS PNNR SASA PASP REMI SLKE RKTD YECT GSNA TYHG AKGE HTSR KDAM TAQN TGIS TLYR NSYG APAE DIKH NQVS AQPV PQEP SRKD YETY QPFQ NSTR NYDE SFFE DQVH HRPP ASEY TMHL GLKS TGNY VDFY SAAR PYSE LNYE TSHY PASP DSWV
Gene ID:1501
Uniprot:Q9UQB3
Cellular Location:Cell junction, Cell projection, Nucleus, Perikaryon, adherens junction, dendrite
Calculated MW:126kDa/132kDa
Observed MW:129kDa
Synonyms:CTNND2, GT24, NPRAP
Background:This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:CTNND2: Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33. Binds to PSEN1. Interacts with RGNEF. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Predominantly expressed in brain; accumulates in cortical neurons. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 5p15.2

Cellular Component: cytoplasm; perikaryon

Molecular Function:beta-catenin binding; protein binding

Biological Process: cell adhesion; signal transduction; synapse organization and biogenesis

Disease: Cri-du-chat Syndrome

NCBI Summary:This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
UniProt Code:Q9UQB3
NCBI GenInfo Identifier:84028193
NCBI Gene ID:1501
NCBI Accession:Q9UQB3.3
UniProt Secondary Accession:Q9UQB3,O00379, O15390, O43206, O43840, Q13589, Q9UM66 Q9UPM3, B0FTZ7,
UniProt Related Accession:Q9UQB3
Molecular Weight:126,529 Da
NCBI Full Name:Catenin delta-2
NCBI Synonym Full Names:catenin delta 2
NCBI Official Symbol:CTNND2  
NCBI Official Synonym Symbols:GT24; NPRAP  
NCBI Protein Information:catenin delta-2
UniProt Protein Name:Catenin delta-2
UniProt Synonym Protein Names:Delta-catenin; GT24; Neural plakophilin-related ARM-repeat protein; NPRAP; Neurojungin
Protein Family:Catenin
UniProt Gene Name:CTNND2  
UniProt Entry Name:CTND2_HUMAN
Anti-CTNND2 Antibody (CAB12633)Western blot analysis of extracts of PC-12 cells, using CTNND2 antibody (CAB12633) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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