Anti-CTBP2 Antibody (CAB0463)
- SKU:
- CAB0463
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CTBP2
- Synonyms:
- C-terminal-binding protein 2
- Research Area:
- Developmental Biology
Description
| Product Name: | CTBP2 Rabbit mAb |
| Product Code: | CAB0463 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CTBP2, C-terminal-binding protein 2 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CTBP2. |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, NIH/3T3, Rat testis |
| Immunogen: | A synthesized peptide derived from human CTBP2. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1488 |
| Uniprot: | P56545 |
| Cellular Location: | Cell junction, Nucleus, synapse |
| Calculated MW: | 47kDa |
| Observed MW: | 47KDa |
| UniProt Protein Function: | CTBP2: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 10q26.13 Cellular Component: transcriptional repressor complex; synapse; cell junction; nucleus Molecular Function:protein binding; retinoic acid receptor binding; transcription coactivator activity; chromatin binding; transcription corepressor activity; NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; white fat cell differentiation; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; viral genome replication; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014] |
| UniProt Code: | P56545 |
| NCBI GenInfo Identifier: | 3182976 |
| NCBI Gene ID: | 1488 |
| NCBI Accession: | P56545.1 |
| UniProt Secondary Accession: | P56545,O43449, Q5SQP7, Q69YI3, Q86SV0, Q9H2T8, A8K2X5 D3DRF5, |
| UniProt Related Accession: | P56545 |
| Molecular Weight: | 106,187 Da |
| NCBI Full Name: | C-terminal-binding protein 2 |
| NCBI Synonym Full Names: | C-terminal binding protein 2 |
| NCBI Official Symbol: | CTBP2 |
| NCBI Protein Information: | C-terminal-binding protein 2; ribeye |
| UniProt Protein Name: | C-terminal-binding protein 2 |
| Protein Family: | C-terminal-binding protein |
| UniProt Gene Name: | CTBP2 |
| UniProt Entry Name: | CTBP2_HUMAN |
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