Cell Biology Antibodies 10
Anti-CST1 Antibody (CAB6570)
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- SKU:
- CAB6570
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CST1 Antibody |
| Antibody SKU: | CAB6570 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-141 of human CST1 (NP_001889.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, A-549, BT-474, THP-1, Mouse large intestine, Rat large intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-141 of human CST1 (NP_001889.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AWSP KEED RIIP GGIY NADL NDEW VQRA LHFA ISEY NKAT KDDY YRRP LRVL RARQ QTVG GVNY FFDV EVGR TICT KSQP NLDT CAFH EQPE LQKK QLCS FEIY EVPW ENRR SLVK SRCQ ES |
| Gene ID: | 1469 |
| Uniprot: | P01037 |
| Cellular Location: | Secreted |
| Calculated MW: | 16kDa |
| Observed MW: | 16kDa |
| Synonyms: | CST1 |
| Background: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. |
| UniProt Protein Function: | CST1: Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. Belongs to the cystatin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20p11.21 Cellular Component: extracellular space Molecular Function:cysteine protease inhibitor activity Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste |
| NCBI Summary: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01037 |
| NCBI GenInfo Identifier: | 311033460 |
| NCBI Gene ID: | 1469 |
| NCBI Accession: | P01037.3 |
| UniProt Secondary Accession: | P01037,Q96LE6, Q9UCQ6, |
| UniProt Related Accession: | P01037 |
| Molecular Weight: | 141 |
| NCBI Full Name: | Cystatin-SN |
| NCBI Synonym Full Names: | cystatin SN |
| NCBI Official Symbol: | CST1 |
| NCBI Protein Information: | cystatin-SN; cystatin 1; cystatin-1; cystain-SA-I; cystatin SA-I; salivary cystatin-SA-1; cysteine proteinase inhibitor, type 2 family |
| UniProt Protein Name: | Cystatin-SN |
| UniProt Synonym Protein Names: | Cystain-SA-I; Cystatin-1; Salivary cystatin-SA-1 |
| Protein Family: | Cystatin |
| UniProt Gene Name: | CST1 |
| UniProt Entry Name: | CYTN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CST1 Antibody (CAB6570) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat brain using CST1 antibody (CAB6570) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate using CST1 antibody (CAB6570) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse stomach using CST1 antibody (CAB6570) at dilution of 1:100 (40x lens). |
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