Developmental Biology

Anti-CSRP3 Antibody (CAB13372)

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SKU:
CAB13372
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-CSRP3 Antibody
Antibody SKU:CAB13372
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human CSRP3 (NP_003467.1).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human CSRP3 (NP_003467.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPNW GGGA KCGA CEKT VYHA EEIQ CNGR SFHK TCFH CMAC RKAL DSTT VAAH ESEI YCKV CYGR RYGP KGIG YGQG AGCL STDT GEHL GLQF QQSP KPAR SVTT SNPS KFTA KFGE SEKC PRCG KSVY AAEK VMGG GKPW HKTC FRCA ICGK SLES TNVT DKDG ELYC KVCY AKNF GPTG IGFG GLTQ QVEK KE
Gene ID:8048
Uniprot:P50461
Cellular Location:Cytoplasm, Nucleus, Z line, cytoskeleton, myofibril, sarcomere
Calculated MW:6kDa/20kDa
Observed MW:
Synonyms:CSRP3, CLP, CMD1M, CMH12, CRP3, LMO4, MLP
Background:This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.
UniProt Protein Function:CSRP3: Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. Defects in CSRP3 are the cause of cardiomyopathy dilated type 1M (CMD1M). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in CSRP3 are the cause of familial hypertrophic cardiomyopathy type 12 (CMH12). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
UniProt Protein Details:

Protein type:Transcription regulation

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: Z disc

Molecular Function:actinin binding; protein binding; structural constituent of muscle; telethonin binding

Biological Process: cardiac muscle contraction; cardiac muscle development; cardiac myofibril assembly; cellular calcium ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; protein localization in organelle; regulation of the force of heart contraction; skeletal muscle development

Disease: Cardiomyopathy, Dilated, 1m; Cardiomyopathy, Familial Hypertrophic, 12

NCBI Summary:This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P50461
NCBI GenInfo Identifier:1705933
NCBI Gene ID:8048
NCBI Accession:P50461.1
UniProt Secondary Accession:P50461,Q9P131,
UniProt Related Accession:P50461
Molecular Weight:20,969 Da
NCBI Full Name:Cysteine and glycine-rich protein 3
NCBI Synonym Full Names:cysteine and glycine rich protein 3
NCBI Official Symbol:CSRP3  
NCBI Official Synonym Symbols:CLP; MLP; CRP3; LMO4; CMD1M; CMH12  
NCBI Protein Information:cysteine and glycine-rich protein 3
UniProt Protein Name:Cysteine and glycine-rich protein 3
UniProt Synonym Protein Names:Cardiac LIM protein; Cysteine-rich protein 3; CRP3; LIM domain protein, cardiac; Muscle LIM protein
Protein Family:Cysteine and glycine-rich protein
UniProt Gene Name:CSRP3  
UniProt Entry Name:CSRP3_HUMAN
Anti-CSRP3 Antibody (CAB13372)Immunofluorescence analysis of HeLa cells using CSRP3 antibody (CAB13372). Blue: DAPI for nuclear staining.
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