Developmental Biology
Anti-CSRP2 Antibody (CAB7549)
- SKU:
- CAB7549
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-CSRP2 Antibody |
| Antibody SKU: | CAB7549 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human CSRP2 (NP_001312.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, SW620, 22Rv1, Mouse lung, Mouse kidney, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human CSRP2 (NP_001312.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPVW GGGN KCGA CGRT VYHA EEVQ CDGR SFHR CCFL CMVC RKNL DSTT VAIH DEEI YCKS CYGK KYGP KGYG YGQG AGTL NMDR GERL GIKP ESVQ PHRP TTNP NTSK FAQK YGGA EKCS RCGD SVYA AEKI IGAG KPWH KNCF RCAK CGKS LEST TLTE KEGE IYCK GCYA KNFG PKGF GYGQ GAGA LVHA Q |
| Gene ID: | 1466 |
| Uniprot: | Q16527 |
| Cellular Location: | Nucleus |
| Calculated MW: | 20kDa |
| Observed MW: | 26-30kDa |
| Synonyms: | CSRP2, CRP2, LMO5, SmLIM |
| Background: | CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CSRP2: a LIM protein that is differentially regulated and preferentially expressed in aortic smooth muscle cells. Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system. |
| UniProt Protein Details: | Protein type:Cell development/differentiation Chromosomal Location of Human Ortholog: 12q21.1 Cellular Component: focal adhesion; nucleus Molecular Function:zinc ion binding Biological Process: multicellular organismal development; cell differentiation |
| NCBI Summary: | CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. [provided by RefSeq] |
| UniProt Code: | Q16527 |
| NCBI GenInfo Identifier: | 4503101 |
| NCBI Gene ID: | 1466 |
| NCBI Accession: | NP_001312.1 |
| UniProt Secondary Accession: | Q16527,Q93030, |
| UniProt Related Accession: | Q16527 |
| Molecular Weight: | 20,954 Da |
| NCBI Full Name: | cysteine and glycine-rich protein 2 |
| NCBI Synonym Full Names: | cysteine and glycine-rich protein 2 |
| NCBI Official Symbol: | CSRP2 |
| NCBI Official Synonym Symbols: | CRP2; LMO5; SmLIM |
| NCBI Protein Information: | cysteine and glycine-rich protein 2; LMO-5; cysteine-rich protein 2; LIM domain only protein 5; smooth muscle cell LIM protein; LIM domain only 5, smooth muscle |
| UniProt Protein Name: | Cysteine and glycine-rich protein 2 |
| UniProt Synonym Protein Names: | Cysteine-rich protein 2; CRP2; LIM domain only protein 5; LMO-5; Smooth muscle cell LIM protein |
| Protein Family: | Cysteine and glycine-rich protein |
| UniProt Gene Name: | CSRP2 |
| UniProt Entry Name: | CSRP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CSRP2 antibody (CAB7549) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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