Cell Biology Antibodies 16

Anti-CSPP1 Antibody (CAB9983)

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SKU:
CAB9983
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CSPP1 Antibody
Antibody SKU:CAB9983
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 962-1221 of human CSPP1 (NP_079066.5).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse
Positive Samples:HeLa, Jurkat, K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 962-1221 of human CSPP1 (NP_079066.5).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QSPK GLDA ATFQ NVHD FNEL KDRD SETR VDLK FMYL DPPR DHHT LEIQ QQAL LREQ QKRL NRIK MQEG AKVD LDAI PSAK VREQ RMPR DDTS DFLK NSLL ESDS AFIG AYGE TYPA IEDD VLPP PSQL PSAR ERRR NKWK GLDI DSSR PNVA PDGL SLKS ISSV NVDE LRVR NEER MRRL NEFH NKPI NTDD ESSL VDPD DIMK HIGD DGSN SVAT EPWL RPGT SETL KRFM AEQL NQEQ QQIP GKPG TFTW QGLS TAHG
Gene ID:79848
Uniprot:Q1MSJ5
Cellular Location:Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle, spindle pole
Calculated MW:101kDa/141kDa/145kDa
Observed MW:145kDa
Synonyms:CSPP1, CSPP, JBTS21
Background:This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
UniProt Protein Function:CSPP1: May play a role in cell-cycle-dependent microtubule organization. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 8q13.2

Cellular Component: centrosome; microtubule organizing center; spindle; spindle pole

Biological Process: positive regulation of cell division; positive regulation of cytokinesis

Disease: Joubert Syndrome 21

NCBI Summary:This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
UniProt Code:Q1MSJ5
NCBI GenInfo Identifier:313104301
NCBI Gene ID:79848
NCBI Accession:Q1MSJ5.4
UniProt Secondary Accession:Q1MSJ5,Q70F00, Q8TBC1, A6ND63,
UniProt Related Accession:Q1MSJ5
Molecular Weight:101,555 Da
NCBI Full Name:Centrosome and spindle pole-associated protein 1
NCBI Synonym Full Names:centrosome and spindle pole associated protein 1
NCBI Official Symbol:CSPP1  
NCBI Official Synonym Symbols:CSPP; JBTS21  
NCBI Protein Information:centrosome and spindle pole-associated protein 1
UniProt Protein Name:Centrosome and spindle pole-associated protein 1
Protein Family:Centrosome and spindle pole associated protein
UniProt Gene Name:CSPP1  
UniProt Entry Name:CSPP1_HUMAN
Anti-CSPP1 Polyclonal Antibody (CAB9983)Western blot analysis of extracts of various cell lines, using CSPP1 antibody (CAB9983) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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